Helix Biopharma Corporation

Other

Promis Neurosciences Inc.

Baomin Tian

Wah Yau Wong

Marni Diane Uger

Heman Lap Man Chao

Sven Rohmann

Kim Gaspar

Neil R Cashman

Jamshid Tanha

Praveen Kumar

Heman Chao

Lakshmi Krishnan

Veronica Ciolfi

Viengthong Chai

Heman Lap-Man Chao

Kimberly Jayne Gaspar

Methods and compositions to restore function to acidified T cells are provided. The methods comprise administering urease to the T cells. Compositions comprise urease.

Restoring function of tumour acidified T cells

Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity.

Antibody-urease conjugates for therapeutic purposes

Compositions and methods for treating cancer in humans are provided using CARs. The invention includes engineered CARs (chimeric receptor antigens) and genetically modified immune cells that express such a CAR with a high affinity for VEGFR. More specifically, the cells are CAR-T cells recognizing VEGFR-2 on solid tumors, uses thereof, compositions thereof and methods of making. The invention includes therapeutic methods to treat VEGFR-2 dependent cancers targeting tumor angiogenesis. A chimeric antigen receptor (CAR) that binds to VEGFR-2, an epitope or fragment thereof, or a variant thereof.

VEGFR-2 car immune cells to treat cancers

A chimeric antigen receptor (CAR) that binds to CEACAM6, an epitope or fragment thereof, or a variant thereof.

CEACAM6 CAR immune cells to treat cancers

Human prion protein, PrP, selectively presents the epitope MDEYSNQNN (SEQ ID No. 14) when PrP misfolds. The misfolded form of human PrP is associated with various disease states. The present invention provides an antibody useful to detect and treat such diseases, including cancer such as ovarian cancer and lymphomas, and transmissible spongiform encephalopathies such as CJD. Also provided is an immunoconjugate in which the antibody is conjugated with urease as cytotoxin.

Antibodies and conjugates that target misfolded prion protein

Growing community of inventors

Edmonton, Canada

Baomin Tian