Koninklijke Philips Corporation N.v.

Baolian Yang

David Leslie Foxall

A magnetic resonance (MR) generating a static (BO) magnetic field of 5 Tesla or higher controller is configured to control an MR scanner to perform an MR sequence () including: performing an excitation/localization sub-sequence () on a subject disposed in the static (BO) magnetic field generated by the MR scanner to excite 1H polarization in a selected spatial region of the subject; performinga polarization transfer sub-sequence () to transfer localized 1H polarization generated by the excitation/localization sub-sequence to a selected species of non-proton nuclei; and performing a magnetic resonance spectroscopy (MRS) readout sub-sequence () to acquire MRS data for the selected species of non-proton nuclei in the selected spatial region of the subject. The polarization transfer sub-sequence includes a pair of phasedistortion canceling trapezoidal 180&#xb0; refocusing pulses () operating on the selected species of non-proton nuclei.

Broad bandwidth magnetic resonance spectroscopy at high static (B0) magnetic field using polarization transfer

A magnetic resonance (MR) sequence () is performed, including: applying a preparatory MR sub-sequence (S prep) providing water signal suppression; performing a magnetic resonance spectroscopy (MRS) sub-sequence (S MRS) after applying the preparatory MR sub-sequence to acquire H MRS data with water signal suppression; and performing an MR reference sub-sequence (S Ref) to acquire MR reference data. The MR reference sub-sequence is performed after the MRS sub-sequence. Phase and B0 correction of the H MRS data with water signal suppression are performed using the MR reference data to generate corrected MRS data. The excitation pulse (g) of the MR reference sub-sequence has a flip angle of less than or equal to o, and more preferably has a flip angle of less than or equal to 3 o. In some embodiments the MR sequence has a total repetition time (TR) of 2000 msec or less.

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Highland Heights, OH, United States of America

Baolian Yang