Sichuan Kelun-biotech Biopharmaceutical Co., Ltd.

Baolei Zhang

Jingyi Wang

Lichun Wang

Jiaqiang Cai

Qiang Tian

Wei Liu

Tianming Wang

Shuai Song

Mingliang Zhao

Chengxi Yang

Yufeng Liang

Hao Hu

Weibiao Han

Youqiang Li

Xing Chen

Disclosed are a solid form of (E)-3-((R)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acrylic acid, a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof in the preparation of drugs for preventing or treating viral diseases.

Solid form of dihydropyrimidine compound and preparation method therefor and use thereof

The present invention relates to compounds represented by formula (I) and formula (II) and a chiral synthesis and chiral isolation method therefor, further relating to a salt and crystal form of the compound represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the preparation of a medicament used for the treatment of a viral infectious disease such as hepatitis B. 

Phosphonamide ester compound, salt thereof, related crystal form thereof, preparation method therefor and use thereof

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Chengdu, China

Baolei Zhang