University of Illinois

Alnylam Pharmaceuticals, Inc.

Philadelphia Health and Education Corporation

Baohua Gu

Timothy Michael Block

Catherine Julia Pachuk

Daniel E McCallus

Robert M Moriarty

Mahendra N Deshpande

Rajendra C Shah

Daniel E Mccallus

Catherine J c/o Nucleonics Inc Pachuk

The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.

Targeting opposite strand replication intermediates of single-stranded viruses by RNAI

An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I) wherein R, R, Rand Rare the same or different and are selected from the group consisting of hydrogen, acyl, benzyl, alkyl, aryl, sulfonyl, phosphonyl, silyl, Ris at least one of alkyl or branched alkyl, heteroalkyl or aryl, R' is a bridging group selected from at least one of bicycle[2.2.1]heptyl, bicycle[3.2.1]octyl, oxa analogs, admonyl and cubyl, n&#x2032;=2-10, n&#x2033;=1-10, enantiomers and stereoisomers of said compounds and physiologically acceptable salts or solvates of said compounds, enantiomer or stereoisomer.

Iminosugar compounds with antiflavirus activity

Growing community of inventors

Malvern, PA, United States of America

Baohua Gu