Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

Other

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Jiangsu Hansoh Medicine Institute Co., Ltd.

Sun, Piaoyang

Baohai Yang

Piaoyang Sun

Jun Yu

Ming Chen

Chengyao Tian

Mingli Zhao

Aifeng Lu

Bigao Pan

Longbin Huang

Chunyong Hu

Sun Piaoyang

A crystal form of 9-[(R)-2-[[(S)-[[[1-(isopropoxycarbonyl)-1-methyl]ethyl]amino]phenoxyphosphinyl]methoxyl]propyl]adenine fumarate of formula (I) is provided. Also provided is a preparation method and method of using the crystal form. Specifically, a crystal form of 9-[(R)-2-[[(S)-[[[1-(isopropoxycarbonyl)-1-methyl]ethyl]amino]phenoxyphosphinyl]methoxyl]propyl]adenine fumarate of formula (I) having an X-ray powder diffraction (XRPD) spectrum including diffraction peaks at 2&#x3b8;&#xb1;0.20&#xb0; of 5.08, 12.44, 13.18, 22.37, 23.37 and 28.56 is provided. The crystal form provided herein has high bioavailability, significant efficacy, good stability, high yield and high purity, and contributes to the selection and design of a drug administration route and the determination of process parameters of a pharmaceutical preparation, thereby improving drug production quality. 

Crystal form of tenofovir prodrug, preparation method thereof, and method of use thereof

Disclosed are organic amine salts of azilsartan, a preparation method and use thereof. In particular, disclosed are organic amine salts of azilsartan, their preparation method, the pharmaceutical composition comprising the compound in a therapeutically effective quantity, and their use for the manufacture of antihypertensive medicaments.

Organic amine salts of Azilsartan, preparation method and use thereof

The present invention provides aminopyrimidine compounds of formula (I) and their salts, wherein R, R, R, R, R, R, Q, Z, L, m, n are defined as the description, the methods for preparation thereof, the uses thereof and the pharmaceutical compositions comprising the effective amount of compounds of formula (I). The compounds of formula (I) and their salts can be used as protein kinase inhibitors. 

Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof

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Lianyungang, China

Baohai Yang