Xiamen University

Hongyun Biotech Co., Ltd.

Baoding Zhang

Xianming Deng

Zhiyu Hu

Li Li

Xihuan Sun

Wei Peng Huang

Shuang Liu

Ting Zhang

Qingyan Xu

Zhou Deng

Jingfang Zhang

Zhixiang He

Yan Liu

Xiaoxing Huang

Xiaoyang Li

Chao Dong

Yunzhan Li

Yun Chen

Yue Lu

Xinrui Wu

A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof

The present invention relates to thienopyrimidine compound, preparation method thereof, pharmaceutical composition and use thereof, and in particular to a type of compounds having ALK and/or c-Met selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with anaplastic lymphoma kinase in vivo, and in the manufacture of a medicament for preventing or treating a disease associated with angiogenesis or cancer metastasis, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis. 

Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof

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Xiamen, China

Baoding Zhang