Aventis Pharmaceuticals Inc.

Sanofi-a Ventis Deutschland Gmbh

Sanofi

Bao-Guo Huang

Heinz-Werner Kleemann

Yulin Chiang

Frank Halley

Gilles Dutruc-Rosset

Yong Mi Choi-Sledeski

Gilles Doerflinger

Gerrit Schubert

Gregory Bernard Poli

David Fink

Joerg Rieke-Zapp

William Arthur Metz, Jr

William Joseph Hurst

Reda Hanna

Joseph T Tsay

Fernando Camacho

Ann Marie Gelormini

Andrew Giovanni

Johannes Keil

Joachim E Roehr

Stephen Wayne Harnish

Xiao-Dong Wu

Yves Gouraud

Juan Antonio Gamboa

Witold Subotkowski

Duane Rudisill

Juan Anotonio Gamboa

Reda G Hanna

Matthew R Powers

Elizabeth Secord

The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I via 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives or 3-(2-carbamoylphenyl)-acrylic ester derivatives as intermediates, to a process for optical resolution, and to intermediates of the process according to the invention.

Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives

The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase I&#x3b5;, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

Substituted 1H-pyrrolo[2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase I&#x3b5;

A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board. In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.

The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon

The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.

Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives

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Bridgewater, NJ, United States of America

Bao-Guo Huang