Trianni, Inc.

Bao Duong

Matthias Wabl

Werner Mueller

Nigel Killeen

Peter Burrows

Matthias Wahl

Christoph Hasenhindl

Gloria Esposito

Peter Daniel Burrows

The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.

Long germline DH genes and long HCDR3 antibodies

The invention provides compositions and methods for enhanced production of immunoglobulin diversity. Specifically, the invention provides compositions and methods for making accessible a B cell receptor repertoire that has not been culled by developmental tolerance mechanisms. The invention also provides transgenic animals, cells, and antibodies resulting from these compositions and methods.

Enhanced immunoglobulin diversity

The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for cell surface capture of secreted immunoglobulin molecules produced endogenously in the plasma cells.

Enhanced production of immunoglobulins

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San Francisco, CA, United States of America

Bao Duong