Drexel University

Philadelphia Health and Education Corporation

Banu Onaral

Scott C Bunce

Kambiz Pourrezaei

Meltem Alkan Izzetoglu

Kurtulus Izzetoglu

Richard B Beard

Patricia A Shewokis

Ajit Devaraj

Saleem Hasan

Kevin J Scoles

Hasan Ayaz

Jay Charles Horrow

Described herein are fNIR-based brain computer interfaces. Training of individuals to intentionally control neural activity in specific cortical areas, thereby up-regulating and down-regulating oxygenation levels in specific locations in the brain is also provided herein. Further, continuous and/or binary control over computing environments using fNIR brain computer interfaces. Further still, a scale for brain interface index for oxygenation of a portion of the brain is provided herein.

Functional near infrared spectroscopy based brain computer interface

Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a patient. The optical density change may be used to obtain a change in deoxyhemoglobin (deoxy-Hb) concentration and/or a change in an oxyhemoglobin concentration (oxy-Hb). The changes in the deoxy-Hb and/or the oxy-Hb may then be compared to determine a state of anesthesia. The effect of artifacts (e.g., strong surgery room lighting, patient-table tilting, patient intubation/extubation) on the fNIR signal may be removed using a noise removal algorithm. In selecting the noise removal algorithm, a switching technique may be used to select the component analysis algorithm, such as a principal component analysis (PCA), an independent component analysis (ICA), or the like.

Functional near-infrared spectroscopy as a monitor for depth of anesthesia

Functional near-infrared (fNIR) neuroimaging is used to assess credibility, detect deception, and implement a query methodology for determining deception via neuroimaging. Oxygenation levels of portions of the brain are imaged via fNIR spectroscopy and utilized to determine if the subject is telling a lie or a truth. In an example configuration, oxygenation levels in the inferior and/or middle prefrontal cortical areas of the brain, such as the bilateral dorsolateral prefrontal and/or inferior frontal cortex, are measured to determine if a subject is lying relative to telling the truth. An example system includes a portable, flexible, belt like sensing device that is positioned proximate the subjects scalp. Sensed neural activity is transmitted either through wired or wireless means, to a processor for analysis of the sensed neural activity. The query methodology utilizes an attestation assertion that mitigates variance in brain responses due to the length or form of a question.

Deception detection and query methodology for determining deception via neuroimaging

An improved method of orthondontic electroosteogenesis comprises providing a biocompatible anode having a noble metal portion in engagement with an electrolytic gel portion comprising agarose and an electrolyte, where the anode gel portion is in engagement with epithelial gingiva at an area of osteoclastic or osteoblastic activity, and a biocompatible cathode having a noble metal portion in engagement with an electrolytic gel portion comprising agarose, an electrolyte, and a weak, biocompatible acid, where the cathode gel portion is in engagement with epithelial gingiva at an area of osteoblastic or osteoclastic activity. Electric current is then applied across the anode and cathode to stimulate osteogenesis. The invention also comprises biocompatible electrodes for electric stimulation of tissue.

Biocompatible electrode and use in orthodontic electroosteogenesis

Growing community of inventors

Philadelphia, PA, United States of America

Banu Onaral