Meiji Dairies Corporation

Meiji Milk Products Company, Limited

Axoglia Therapeutics S.a.

Meiji Co., Ltd.

Bang Luu

Masashi Yamada

Hiroto Suzuki

Yukie Suma

Djalil Coowar

Ellane Mohier

Masao Miyagawa

Takeshi Watanabe

Motoaki Saito

Gaby Schmitt

Jean-Philippe Loeffler

Thierry Muller

Yukio Ohshiba

Florence Keyling

Celine Junges-Girlanda

Philippe Chabert

Jose-Luis Gonzalez De Aguilar

Bernadette Lutz-Bucher

Delphine Trancard

Celine Girlanda-Junges

Florence Keyling-Bilger

Patrick Neuberg

Eleonora Morga

Paul Heuschling

Mazen Hanbali

Dominique Bagnard

H Meiji Dairies Corp Pharmaceut Dept Suzuki

Hirohito Fukuyama University Shiomi

M Meiji Dairies Corp Pharmaceut Dept Yamada

Yutaka Fukuyama University Tamura

K Meiji Dairies Corp Pharmaceut Dept Koyama

Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): 

Indole derivatives substituted with long-chain alcohols and medicaments containing them

The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

Hydroquinone long-chain derivatives and/or phenoxy long-chain derivatives, and pharmaceuticals comprising the same

The present invention relates to an agent for suppressing STAT3 phosphorylation and for suppressing Notch1 expression comprising as an active ingredient a compound represented by the following formula (1): 

STAT3 phosphorylation inhibitor and notch1 expression inhibitor

A preventive and/or therapeutic agent for diabetes complications, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): wherein, R, Rand Reach independently represents a hydrogen atom or a methyl group and X represents a linear or branched Calkylene or alkenylene group. The cyclohexenone long-chain alcoholic derivative of the present invention significantly suppresses a reduction in a peripheral nerve conduction rate and alleviates the hypofunction of the bladder so that it is useful as a preventive and/or therapeutic agent for diabetes complications, particularly, for diabetic neuropathy. 

Use of cyclohexenone derivatives in the manufacture of a medicament for treating diabetic complications

The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia an/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula.

Tocopherol derivatives with a long hydroxylated chain, which can be used as neurotrophics

Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R, R, Rand Reach independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number fromtoand a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

An indole derivative represented by the following general formula (1): 

Indole derivatives and drugs containing the same

A process for producing cyclohexenone long-chain alcohol represented by the following formula (1): (wherein A represents a C10-C18 alkylene or alkenylene group, and each of R, R, and Rindividually represents hydrogen or methyl), comprising reacting a 3-alkoxy-2-cyclohexen-1-one derivative represented by the following formula (2): (wherein R, R, and Rhave the same meanings as above, and Rrepresents a C1-C5 alkyl group) with a Grignard's reagent prepared by protecting the hydroxyl groups of C10-C18 &#x3c9;-halogenoalcohol through silylation, and hydrolyzing the resultant reaction product. The process of the present invention for producing cyclohexenone long-chain alcohol requires a reduced number of reaction steps, can be performed with ease and with reduced production cost, and thus finds utility in the industry 

Process for producing cyclohexenone long-chain alcohols

A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R, R, and Rrepresents a hydrogen atom or a methyl group; and X represents a C10&#x2013;C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.

Use of cyclohexenone long-chain alcohol for treating neurodegenerative diseases

A preventive and/or therapeutic agent for dysuria, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the following formula (1): [wherein, R, Rand Reach independently represents a hydrogen atom or a methyl group and X represents a linear or branched Calkylene or alkenylene group]. This compound alleviates dysuria due to hypofunction of the urinary bladder so that they are useful as a preventive and/or therapeutic agent for dysuria

Use of cyclohexenone derivatives for the manufacture of a medicament in the treatment of dysuria

Described is a cyclohexenone long-chain alcohol represented by the formula (1):

Cyclohexenone long-chain alcohol and medicament containing same

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Strasbourg, France

Bang Luu