Council of Scientific and Industrial Research

Bandari Rajendra Prasad

Ahmed Kamal

Adla Malla Reddy

The present invention relates to chalcone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation there of. More particularly it relates to 7-Methoxy-8-{n[4-1-(2 or 4-substituted phenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one]alkyl}-oxy}-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one and 7-Methoxy-8-{n-[-3-(4-hydroxy-3-methoxyphenyl)-1-(2,4-alkyl-3-quinolyl)-2-propen-1-one]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one with aliphatic chain length variations useful as anticancer (antitumor) agent. The general structural formula of these chalcone linked pyrrolo[2,1-c][1,4]benzodiazepines hybrids is given below. wherein R=OH, methyl, ethyl or phenyl; R=H, OH or F; R=H or methyl; x=c or N; n=1-4. 

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Disclosed herein are benzophenone hybrids with potent anticancer activities and processes for creation of the same.

Benzophenone hybrids as anticancer agents and processes for the preparation thereof

The present invention provides novel anthranilic acid derivative useful as potential anticancer agent. More particularly, the present invention relates novel anthranilic acid derivative of general formula (8), R'=alkyl-2-methoxyphenyl piperazine or benzyl; R=2-methoxyphenyl, piperazine, 2-pyridyl piperazine-1-yl, 2-pyrimidyl piperazine-1-yl, 4-quinazolinyl piperazine-1-yl, 9H-9-fluorenylamine, 4-{(2{amino-5-(methoxy)-4-[(phenylmethyl)oxy]phenyl}carbonyl)-hexahydro-1-pyrazinyl], and [(4[2-amino-4-(benzyloxy)-5-methoxybenzoyl]aminophenyl)-sulfonyl]-4-benzamine; X&#x2550;H or pyrazine-2-carbonyl. The present invention also provides a process for the preparation of novel anthranilic acid derivative of general formula (8), which is useful as potential anticancer agent. 

Substituted piperazine compounds of formula 8

The present invention provides a compound of general formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formula (5): wherein n=3, 4, 5, 6, 8 and wherein R1 and Ris selected from the group consisting of R&#x2550;H, R&#x2550;H or R&#x2550;CHO, R2=CHO or R&#x2550;CHO and R&#x2550;CHO. 

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Andhra Pradesh, India

Bandari Rajendra Prasad