King Fahd University of Petroleum and Minerals

Bandar Aldhubiab

Katharigatta N Venugopala

Mohamed A Morsy

Pran Kishore Deb

Anroop B Nair

Mahesh Attimarad

Nagaraja Sreeharsha

Sandeep Chandrashekharappa

Melendran Pillay

Vinuta Kamat

Boja Poojary

Rangappa Santosh

Vijay M Kumbar

Manohar S Kugaji

Vijaykumar Uppar

Sheena Shashikanth

Basavaraj Padmashali

Christophe Tratrat

Mahmoud Kandeel

Osama I Alwassil

Rashmi Venugopala

Raghu Prasad Mailavaram

Pramod Dhanaji Patil

Nizar A Al-Shar'i

Praveen B Managutti

Gabriella Marucci

Buccioni Michela

Sandeep Chandrashekarappa

Sonia Kundu

Suvadra Das

Aalok Basu

Teeka Sathiesh Roopashree

Partha Roy

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds of formula 4 as identified below that are 5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents, with the substituents defined as stated herein.

5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as antibacterial agents

Novel 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, are useful as anti-tubercular agents.

1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide as anti-tubercular agents

Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds that are 5-(substituted phenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents. The compounds having the formula 4:

Compounds for treating an inflammatory disease, disorder, or condition and, particularly, to compounds that are 5-(substitutedphenyl)-7-imino-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-inflammatory agents.

5-(Substitutedphenyl)-7-Imino-7,8-Dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as anti-inflammatory agents

Adenosine receptor active compounds including 1,2,3,6,8-pentasubstituted indolizines and methods of using the same for inhibiting adenosine receptor activity are provided. These methods can be used to treat one or more pathological conditions of the central and peripheral nervous systems, such as but not limited to allergies, inflammation, glaucoma, brain ischemia, renal fibrosis, cancer, rheumatoid arthritis, psoriasis fatty liver diseases, stroke, pain, and any combination thereof.

Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates

Compounds for treating cancer and, particularly, to compounds that are 5-(3-substituted phenyl)-pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione analogues and their use as anticancer agents.

5-(3-substituted phenyl)-pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione derivatives as anticancer agents

Novel dimethyl 7-bromo-1-(4-substituted benzoyl)pyrrolo[1,2-α]quinoline-2,3-dicarboxylates compounds, having the structure: A method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The dimethyl 7-bromo-1-(4-substituted benzoyl)pyrrolo[1,2-α]quinoline-2,3-dicarboxylates compounds, identified as anti-inflammatory agents, are useful for treating inflammation, pain, and swelling in a patient.

Dimethyl 7-bromo-1-(4-substituted benzoyl)pyrrolo[1,2-a]quinoline-2,3-dicarboxylates as anti-inflammatory agents

Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are 1-(2-(substitutedphenyl)-2-oxoethyl)-3,5-dimethylpyridin-1-ium bromides and their use as anti-tubercular agents.

1-(2-(substituted phenyl)-2-oxoethyl)-3,5-dimethylpyridin-1-ium bromides as antitubercular agents

Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are ethyl 2-substitued-1-(substitutedbenzoyl)-7-methylpyrrolo[1,2-a]quinoline-3-carboxylate derivatives and their use as anti-tubercular agents are provided.

Ethyl 2-substituted-1-(substitutedbenzoyl)-7-methylpyrrolo[1,2-a]quinoline-3-carboxylate derivatives as anti-tubercular agents

Compounds for treating cancer and, particularly, to compounds that are 5-(3-substituted phenyl)-pyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,8H)-trione analogues and their use as anticancer agents. The compounds have the structure: wherein: Ris selected from the group consisting of hydrogen, hydroxy, and benzyloxy; Ris selected from the group consisting of hydrogen, a C-Cstraight or branched chain alkoxy, and benzyloxy; Ris selected from the group consisting of hydrogen and a C-Cstraight or branched chain alkyl; and Ris selected from the group consisting of hydrogen and a C-Cstraight or branched chain alkyl.

Antifungal compounds and, particularly, to antifungal compounds that are 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4H-1,2,4-triazole-3-thiol derivatives and their use as antifungal agents.

4-amino-5-(4-fluoro-3-phenoxyphenyl)-4H-1,2,4-triazole-3-thiol derivatives as antifungal agents

Compounds for treating tuberculosis and, particularly, antitubercular compounds that are substituted 7-methyl quinoline derivatives and their use as antitubercular agents are provided.

Substituted 7-methyl quinoline derivatives as antitubercular agents

Novel-(-(substituted phenyl)--oxoethyl)--(isopropoxycarbonyl)pyridin--ium bromide derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The-(-(substituted phenyl)--oxoethyl)--(isopropoxycarbonyl)pyridin--ium bromide derivative compounds are useful as anti-tubercular agents.

1-2(-(substituted phenyl)-2-oxoethyl)-4-(isopropoxycarbonyl)pyridin-1-ium bromides as anti-tubercular agents

Compounds for treating tuberculosis and, particularly, antitubercular compounds that are 1-substituted benzoyl-4-bromopyrrolo[1,2-a]quinoline-3-carboxylate derivatives and their use as antitubercular agents are provided.

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Bandar Aldhubiab