Council of Scientific and Industrial Research

Piramal Life Sciences Limited

Balram Ghosh

Chandrika Rao

Samir Kumar Brahmachari

Pallav Bhatnagar

Ritushree Kukreti

Randeep Guleria

Chinmoyee Das

Jhillu Singh Yadav

Santu Bandyopadhyay

Rakesh Kamal Johri

Subhash Chander Sharma

Siddhartha Roy

Aditya Konar

Bholanath Paul

Radha Krishna Palakodety

Arun Bandyopadhyay

Gurdarshan Singh

Mabalirajan Ulaganathan

Vasanta Madhava Sharma Gangavaram

Rana Nagarkatti

Debaprasad Jana

Tanima Banerjee

Dipak Kar

Tulika Mukherjee

Mumu Chakraborty

Sibabrata Mukhopadhyay

The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients. Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below:  Herbal route for the isolation of compound of general formula 1 from the bark of plantand chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

Method for treatment of bronchial asthma

Present invention relates to a method for predicting an individual's bronchodilatory response to a &#x3b2; agonist. Present invention particularly relates to the detection of specific allelic variants of the &#x3b2;2AR gene and their use as pharmacogenetic markers towards response to &#x3b2; agonist.

Primers for amplifying and detecting the beta 2 adrenergic receptor gene

Method of detecting and predicting bronchodilatory response to beta agonist

The present invention relates to allelic variants of the human Signal Transducer and Activator of Transcription-6 (STAT6) gene and provides primers and methods suitable for the detection of these allelic variants for applications such as molecular diagnosis, prediction of an individual's disease susceptibility, and /or the genetic analysis of the STAT6 gene in a population. Specifically, the invention provides a method for detection of predisposition to atopic disorders/other immunological disorders such as, autoimmune disorders, inflammatory disorders, fibrosis, etc. where STAT6 plays an important role by screening for human Signal Transducer and Activator of Transcription-6 (STAT 6) gene variants.

Gene variants of signal transducer and activator of transcription-6 (STAT 6) variants and process of detection the same

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New Delhi, India

Balram Ghosh