Institute of Radiation Medicine, Academy of Military Medical Sciences, Pla.

Institute of Radiation Medicine

Baiping Ma

Chengqi Xiong

Hao Chen

Jie Zhang

Yang Zhao

Yue Gao

Liping Kang

Junxing Dong

Bingji Wang

Dawei Tan

Yuwen Cong

Quiping Xu

Qiuping Xu

A method for preparation of Timosaponin BII, which uses Chinese traditional medicine Rhizoma Anemarrhenae or fresh rhizoma or fibrous root ofBge. as raw material, and comprises isolation of Timosaponin BII by one or more processes selected from solvent extraction, resin adsorption, polyamide chromatography, reversed phase column chromatography, Sephadex LH-20 column chromatography, etc, combining with conventional drying method such as reduced pressure drying, freeze drying, spray drying, and so on. Timosaponin BII obtained by the present method is of over 90% purity, and the method is simple, practicable and suitable for industrial production.

Process for preparation of timosaponin B II

The invention disclosed the use of timosaponin BII in the preparation of a medicament or product for the prevention and treatment of stroke. The experiments prove that timosaponin BII can improve the neurological symptoms of cerebral ischemic rat, reduce infarct size, relieve brain water edema, improve hemorheology, reduce inflammatory injury of cerebral ischemia.

Use of timosaponin Bll in the preparation of a medicament or product for the prevention and treatment of stroke

The invention relates to the steroidal saponin compounds for the propylaxis or treatment dementia, the new steroidal saponin compounds and the pharmaceutical composition containing the same.

Use of steroidal saponins for the prophylaxis or treatment of dementia, and novel steroidal saponin compounds

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Beijing, China

Baiping Ma