Applied Molecular Evolution

Janssen Biotech, Inc.

Centocor, Inc.

Other

Johnson and Johnson Vision Care, Inc.

Centocor Ortho Biotech Inc.

Bailin Liang

David M Knight

Alain Philippe Vasserot

Raymond W Sweet

David J Shealy

Sheng-Jiun Wu

David Matthew Marquis

Jing Yang

Vedrana Stojanovic-Susulic

Eric Michael Smith

Debra Gardner

Michael W Lark

Yan Chen

Susan H Tam

Xiao-Yu R Song

Xiao-yu R Song

Michael Naso

Keying Ma

Robert T Sarisky

Anuk Das

Chong C Huang

Li Li

Xiaozhou Shang

Donald E Griswold

Susan Tam

Zhenyu Li

Yan Chan

Chris Huang

Peter Bugelski

Don E Griswold

Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.

Anti-IL-6 antibody

Disclosed herein are methods for quantifying contact lens deposition. An example method may comprise disposing a contact lens sample in a fluid well. The example method may comprise disposing a volume of tear fluid in the well with the contact lens sample. The example method may comprise capturing pre-rinse images of the contact lens sample. The example method may comprise rinsing the contact lens sample. The example method may comprise capturing post-rinse images of the contact lens after the rinsing. The example method may comprise determining, using one or more of the tear images or the post-rinse images, a deposition metric. The example method may comprise outputting the deposition metric.

Microfluidic device and method for quantifying contact lens deposition

Methods of suppressing rheumatoid arthritis using an anti-IL-6 antibody

A pen-injector device comprising an anti-IL-6 antibody with a liquid formulation have applications in diagnostic and/or therapeutic compositions, methods and devices.

Pen-injector device containing anti-IL-6 antibodies

An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibodies, compositions, methods and uses

Anti-IL-6 antibodies

Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNF&#x3b1; antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.

CXCL13 antagonists and their use for the treatment of inflammatory diseases

Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.

Methods of treating conditions using anti-IL-6 antibodies

Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Anti-IL-6 antibody nucleic acid molecules and methods

Anti-il-6 antibodies, compositions, methods and uses

Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses

Growing community of inventors

Gilbertsville, PA, United States of America

Bailin Liang