Alcon Laboratories, Inc.

Alcon Manufacturing, Ltd.

Alcon Research, Ltd.

Other

Novartis Ag

Bahram Asgharian

Bor-Shyue Hong

Ronald P Quintana

Masood A Chowhan

Ruth A Rosenthal

Thierry Bilbault

Joonsup Park

Malay Ghosh

Paul E Stach

Mandar V Shah

Gerald D Cagle

Wesley Wehsin Han

Nissanke L Dassanayake

Ernesto J Castillo

Martin B Wax

Ronald L Schlitzer

Kerry L Markwardt

Alok K Kulshreshtha

Wesley Weshin Han

The present invention generally relates to suspension compositions having a carboxyvinyl polymer such as a carbomer, a galactomannan such as guar, and a borate compound. A sparingly soluble particulate compound such as nepafenac is also included in the compositions. The sparingly soluble particulate compound has a small particle size to enhance bioavailability of the compound.

Carboxylvinyl polymer-containing nanoparticle suspensions

Carboxyvinyl polymer-containing nanoparticle suspensions

The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives.

Use of low molecular weight amino alcohols in ophthalmic compositions

Disclosed is a pharmaceutical composition comprising (a) a bioerodible water insoluble polymer matrix comprising a polyester polymer, wherein the polymer matrix has a melting point of less than 60&#xb0; C. and (b) an active agent dispersed within the polymer matrix, wherein the composition is formulated to controllably release the active agent for a pre -determined period of time to a target site. Also disclosed are methods of treating a disease or condition with the disclosed compositions.

Water insoluble polymer matrix for drug delivery

The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions to the eye.

Ophthalmic compositions containing galactomannan polymers and borate

The present invention is directed to viscoelastic systems comprising a combination of a galactomannan polysaccharide containing composition and borate containing composition. The two compositions gel or partially gel upon combination. The present invention also discloses methods of using the systems during surgery and, in particular, eye surgery.

Methods of performing surgery with galactomannan polymers and borate

Contact lens care compositions for the treatment of hard contact lenses are disclosed. The compositions are useful for rinsing, cleaning, disinfecting and storing of hard contact lenses. The compositions contain an unique gelling system involving galactomannan polysaccharides and borates to allow for the conditioning of the lens when it is reinserted in the eye of the user. Methods of using these compositions are also disclosed.

Solutions for treating contact lenses

The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions of the eye.

Improved stability, liquid enzyme compositions containing an alkylated trypsin and methods involving the combined use of these compositions with an aqueous composition are disclosed for the cleaning or simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.

Alkyl trypsin compositions and methods of use in contact lens cleaning and disinfecting systems

Growing community of inventors

Arlington, TX, United States of America

Bahram Asgharian