Visen Medical, Inc.

Applied Research Systems Ars Holding N.v.

Bagna Bao

Kevin Groves

Gian Luca Araldi

Sean D McKenna

Zhong Zhao

Adulla P Reddy

The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.

Carbonic anhydrase targeting agents and methods of using same

1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.

Gamma lactams as prostaglandin agonists and use thereof

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Sharon, MA, United States of America

Bagna Bao