Musc Foundation for Research Development

University of Colorado

The United States Government As Represented by the Department of Veterans Affairs

Peterson, Yuri Karl

Rohrer, Baerbel

Beeson, Craig, C.

Lindsey, Christopher, C.

Baerbel Rohrer

Craig Cano Beeson

Christopher C Lindsey

Yuri Karl Peterson

V Michael Holers

Stephen Tomlinson

Gary Gilkeson

Robert Gourdie

Michael Holers

Craig C Beeson

Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders. 

Oxindole compounds and pharmaceutical compositions thereof

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders

Isatin compounds, compositions and methods for treatment of degenerative diseases and disorders

Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders

The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.

Targeting complement factor H for treatment of diseases

Growing community of inventors

Charleston, SC, United States of America

Baerbel Rohrer