Council of Scientific and Industrial Research

Badari Narayana Prasad Rachapudi

Venkata Padmaja Korlipara

Satya Bhaskar Potula

Venkata Surya Koppeswara Rao Bhamidipati

Saravanan Krishnasamy

Rajkumar Banerjee

Arun Kumar Singh

Penumarthy Vijayalakshmi

Pradosh Prasad Chakrabarti

Vandana Vemulapalli

Ramakrishna Sistla

Vijayalakshmi Penumarthy

Kasturi Venkata Sesha Adinarayana Rao

Madhusudhana Kuncha

Sri Lakshmi Karuna Marellapudi

Sayantani Roy

Lakshmi Anu Prabhavathi Devi Bethala

Vamanrao Diwan Prakash

Nadpi Gangadhar Katkam

Vijayalakshmi Kunkuma

Karunakar Reddy Rondla

Vijayalakshi Kunkuma

The present invention relates to a formulation in which glycolipids and phospholipids, isolated from rice bran gum samples, were used in conjunction with gene carrying lipids to test its efficacy in delivering genes to cancer cells selectively. This formulation did not mediate efficient delivery of genes to non-cancerous cells, thus, showing potential use of this formulation to deliver anticancer therapeutics to cancer cells without eliciting treatment related toxicity to normal cells.

Rice bran-lipids based formulation and process for preparation thereof for selective delivery of genes to cancer cells

Hexadecyl cis-9-tetradecenoate commonly known as Cetyl myristoleate (CMO) is being used for the treatment of osteoarthritis and other joint inflammatory diseases, cis-9-Tetradecenoic acid (cis-9-myristoleic acid) is the main precursor for the preparation of CMO. As there are limited natural plant sources for cis-9-tetradecenoic acid, the present invention aimed at the synthesis of cis-9-tetradecenoic acid methyl ester from oleic acid methyl ester. As oleic acid is not available in pure form, this has to be isolated from oleic acid-rich oils like olive oil. cis-10-Tetradecenoic acid methyl ester, an isomer of cis-9-tetradecenoic acid was also prepared from undecenoic acid methyl ester, a derivative of castor oil. Undecenoic acid is easily available commercially in pure form. Hexadecyl cis-9-tetradecenoate and hexadecyl c/s-10-tetradecenoate were prepared by enzymatic transesterification of cis-9-tetradecenoic acid methyl ester and cis-10-tetradecenoic acid methyl ester with 1-hexadecanol (cetyl alcohol) respectively. Both the isomers of cetyl myristoleate were evaluated for anti arthritis, blocking inflammation and reduction of adjuvant-induced arthritis in rats.

Process for preparation of hexadecyl cis-9-tetradecenoate and hexadecyl cis-10-tetradecenoate

Castor oil was hydrolysed to castor fatty acids and self condensed to get a ricinoleic acid-based estolide of about 95 acid value. The carboxylic group of the estolide on subsequent esterification with linear or branched chain alcohols and also on acetylation of free hydroxy group yielded castor oil fatty acids based estolide esters and their acetates. All the products were evaluated for total acid number (TAN), viscosity, viscosity index, pour point, flash point, and copper strip corrosion and found to be potential lubricant basestocks.

Castor oil fatty acid based estolide esters and their derivatives as potential lubricant base stocks

A new class of oleochemical based polyol esters of general formula 1 are prepared by esterification of different polyols having 5-6 carbon atoms and 2-4 hydroxyl groups with 10-undecenoic acid or/and undecanoic acid with a hydroxyl value of &#x2266;1.0 mg KOH/g. Wherein R, R, Ris selected from a group consisting of CH&#x2014;, CHCH&#x2014;, &#x2014;CHOCORwherein Ris selected from CH&#x2550;CH&#x2014;(CH)&#x2014; or CH&#x2014;(CH)&#x2014;, individually or in combination thereof. The resulting esters were characterized for lubricant properties like viscosity, viscosity index, pour point, flash point and copper corrosion tests. The properties indicate their potential as promising lubricant base stocks for automotive lubricants, metal working oil, hydraulic oil and other industrial applications. Vegetable oils provide most of the desirable lubricant properties such as good boundary lubrication, high viscosity index, high flash point and low volatility. Synthetic esters prepared from renewable resources like vegetable oils exhibit better performance at a lower cost compared to mineral oil based synthetic esters. 

Polyol esters of medium chain fatty acids and process for preparation thereof

The present invention relates to modification of the chemical structure of ricinoleic acid, which is present to an extent of 85-90% in castor oil into triacyloxy alkyl ester derivatives. Accordingly, 9,10,12-trihydroxy octadecanoic acid rich fatty acid mixture was prepared from castor oil and converted to their alkyl esters followed by acylation of hydroxy groups to get 9,10,12-triacyloxy octadecanoic acid alkyl ester rich fatty acid alkyl esters mixture. The 9,10,12-triacyloxy octadecanoic acid alkyl esters were purified from the crude product and characterized byH NMR studies. The crude products were also evaluated for acid value (A.V.), hydroxyl value (H. V.), iodine value (I. V.), viscosity, viscosity index (V.I.), pour point, flash point and copper strip corrosion and found to be potential base stocks for hydraulic, metal working fluids and other industrial fluids.

9,10,12-triacyloxy octadecanoic acid alkyl ester and 9,10,12-triacyloxy octadecanoic acid alkyl ester rich fatty acid alkyl esters mixture and a process for preparation thereof

The present invention provides a process for the enrichment of methyl ricinoleate from castor oil methyl esters by liquid-liquid extraction (LLE) in presence of refined vegetable oils using an aqueous polar solvent. The invention provides an extraction of methyl ricinoleate by a non-destructive extraction method with good yields (75 to 90%) and purity (95 to 99%). The method consists of mixing castor oil methyl esters in a refined normal vegetable oil (feed) in a suitable proportion and selective extraction of methyl ricinoleate in a non-destructive manner by liquid-liquid extraction using a polar aqueous solvent, followed by de-solventization and drying of the solute to get enriched methyl ricinoleate fraction with good yields. The non-hydroxy fatty acid methyl esters of castor oil methyl esters are retained in the vegetable oil and can be used for the preparation of biodiesel or oelochemicals or reused in the process for the enrichment of methyl ricinoleate after removal of non-hydroxy fatty acid either by distillation under reduced pressure or further by liquid-liquid extraction using pure solvent.

Process for the enrichment of methyl ricinoleate from castor oil methyl esters by liquid-liquid extraction

The present invention provides an enzymatic process for the preparation of an acetylated phospholipid from a lecithin by acetylating the lecithin in the presence of vinyl acetate and a catalyst comprising lipase from having 1,3-position specificity, separating the desired acetylated phospholipid.

Enzymatic process for the preparation of an acetylated phospholipid

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Hyderabad Telangana, India

Badari Narayana Prasad Rachapudi