Emcure Pharmaceuticals Limited

Council of Scientific and Industrial Research

Baburao Manikrao Bhawal

Milind Moreshwar Gharpure

Satish Ramanlal Mehta

Prasad Vasudeo Ranade

Rajendra Dagadu Deshmukh

Srinivasachari Rajappa

Abdul R Deshmukh

Rajiv Pandurag Sutar

Vasudeo P Shiralkar

Umesh Rewaji Zope

Viral Bipinbhai Shah

The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or (S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution.

Process for producing enantiomer of amlodipine in high optical purity

The present invention relates to a cost-effective process for manufacture of iron sucrose complex.

Cost-effective process for preparation of manufacture of iron sucrose

A process is disclosed for the manufacture of 1-substituted amino-1-substituted thio-2 nitro alkenes of the general formula: (R1NH) (R2S) C.dbd.CR3 (NO2) wherein R1, R2, R3, may be same or different and may consist of hydrogen, alkyl, aryl or arylalkyl groups or combinations thereof. These alkenes are prepared by reacting a primary amine with a compound of sulfur in the presence of a primary catalyst to obtain a carbonimidodithioic acid salt which is converted to a corresponding ester which is thereafter reacted with a nitro compound in the presence of a secondary catalyst. 1-methylamino-1-methylthio-2-nitroethene is an important intermediate in the synthesis of Rantitidine and Nizatidine which are used as effective drugs in the treatment of peptic ulcers and associated gastrointestinal disorders.

Improved process for the preparation of 1-substituted

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Maharashtra, India

Baburao Manikrao Bhawal