Other

Biomira, Inc.

Oncothyreon Inc.

Agrawal, Babita

Kumar, Rakesh

Gupta, Nancy

Babita Agrawal

Rakesh Kumar

B Michael Longenecker

Nancy Gupta

D Lorne J Tyrrell

Mark J Krantz

Mark A Reddish

Michael B Longenecker

The present disclosure provides immunomodulatory compositions comprising live(CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.

Immunomodulatory compositions and methods of use thereof

The present disclosure provides immunomodulatory compositions comprising heat-killed(HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.

Disclosed are nucleosides which are useful in diagnosing and treating viral infections, for example, infections caused by hepatitis B virus (HBV), and herpes viruses including Epstein Barr virus.

Antiviral nucleosides

Methods of detecting activated T-cells involve monitoring levels of MUC-1 mucin expression at the protein and/or mRNA level. Compositions for modulating immune function contain compounds that modulate the expression or function of MUC-1. Methods of treating disorders associated an inappropriate state of T-cell activation involve contacting a T-cell with a compound containing an inhibitor of MUC-1 expression or function.

Methods of detecting T-cell activation

A method for generating a mixture of activated T-cells by combining a plurality of peripheral blood lymphocytes (PBLs) with an antigen-loaded liposome to produce antigen-loaded PBLs, and combining the antigen-loaded PBLs with a naive, anergic or memory T-cell, to produce an activated T-cell. Such activation is carried out in vivo or in vitro. The antigen-loaded PBLs and activated T-cells, prepared according to the methods of invention, have use as cellular vaccines for treatment of cancer and viral diseases.

Growing community of inventors

Edmonton, Canada

Babita Agrawal