Synovis Life Technologies, Inc.

Biovascular, Inc.

B Nicholas Oray

Daniel L Mooradian

Ralph T Francis

Amy DeSmith

Qing Hong Zhao

William F Kuester

A combination medical device comprising a circular stapler instrument () and one or more portions of preformed buttress material () adapted to be stably positioned upon the staple cartridge () and/or anvil () components of the stapler () prior or at the time of use. Positioned buttress material(s) () are delivered to a tissue site where the circular stapler () is actuated to connect previously severed tissue portions. An embodiment of the invention allows tissue portions to be joined without the use of sutures. The buttress material () is made up of two regions, one of which serves primarily to secure the buttress material () to the stapler () prior to actuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler () to form anastomoses, while the remaining material secures and seals the newly connected tissue. Methods of use and preparation of the buttress material () are also described.

Circular stapler buttress combination

The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and/or surgical articles involved in the surgery are separated by a biomaterial provided in the form of a non-crosslinked, decellularized and purified mammalian tissue (e.g. bovine pericardium). The biomaterial effectively inhibits fibrosis, scar formation, and surgical adhesions, while also serving as a scaffold for recellularization of the tissue site.

Method of preventing surgical adhesions

A combination medical device comprising a circular stapler instrument and one or more portions of preformed buttress material adapted to be stably positioned upon the staple cartridge and/or anvil components of the stapler prior or at the time of use. Positioned buttress material(s) are delivered to a tissue site where the circular stapler is actuated to connect previously severed tissue portions. The buttress material is retained and provides an improved seal between the joined tissue sections. The buttress material is made up of two regions, one of which serves primarily to secure the buttress material to the stapler prior to actuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler to form an anastomoses. Methods of use and preparation of the buttress material are also described.

A non-crosslinked, decellularized and purified mammalian tissue (e.g., bovine pericardium) having particular use as an implantable resorbable material. The material is treated by alkylating its primary amine groups in a manner sufficient to reduce the antigenicity of the tissue, permitting the treated tissue to be used in vivo and without crosslinking, and in turn, permitting it to be resorbable. The material can be used in surgical repair of soft tissue deficiencies for a certain period of time while the implant itself is gradually remodeled or absorbed by the host. Also provided are a method of preparing such a material, as well as a method of using such a material for surgical repair.

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Woodbury, MN, United States of America

B Nicholas Oray