Abbott Laboratories Corporation

B Gregory Donner

David S Garvey

Wang Shen

Gerard M Sullivan

Todd Warren Rockway

Saul H Rosenberg

Anthony K Fung

Stephen J O'Connor

William R Baker

Stephen A Fakhoury

Rajnandan N Prasad

William J McClellan

David M Stout

Herman H Stein

The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.

Inhibitors of squalene synthetase and protein farnesyltransferase

The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

Inhibitors of protein farnesyltransferase and squalene synthase

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Mundelein, IL, United States of America

B Gregory Donner