Kao Corporation

Azumi Nagasawa

Mitsuyoshi Sakasai

Shigeru Moriwaki

Noriko Ito

Michiyo Sasajima

Megumi Matsuoka

Susumu Ichinose

Yusuke Shibuya

The present invention provides a method for controlling hair growth, a method for selecting or evaluating a hair growth control agent, and a hair growth suppression agent. The present invention provides a method for selecting or evaluating a hair growth control agent, including the steps of administering a test substance to a cell capable of expressing DnaJC6; measuring the expression of DnaJC6 in the cell; and evaluating the controlling effect of the test substance on hair growth based on the expression. The present invention also provides a hair growth suppression agent containing funabarasou () or its extract as the active ingredient.

Method for controlling hair growth, method for selecting or evaluating hair growth control agent, and hair growth suppression agent

To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth-promoting effect. The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.

NFAT signal inhibitor and calcineurin inhibitor

An NFAT signal inhibitor and the like are provided. An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where in the formula (I), Rand R, which may be identical with or different from each other, each represent a hydrogen atom or a group represented by formula (II) (where in the formula (II), Rrepresents a linear or branched alkyl or alkenyl group having 1 to 20 carbon atoms)] and pharmacologically acceptable salts thereof.

NFAT signal inhibitor and hair-growing agent

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Haga-gun, Japan

Azumi Nagasawa