Abbott Laboratories Corporation

Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Azad Hossain

Chris Hugh Senanayake

Nathan K Yee

Xudong Wei

Suresh R Kapadia

Nizar Haddad

Carl Alan Busacca

Fabrice Gallou

Jianxiu Liu

Xiu Chun Wang

Ashok V Bhatia

Steven A Chamberlin

Arthur J Cooper

Denton C Langridge

Timothy B Towne

John J Hufnagel

Jufang Barkalow

Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN:  The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

Process for preparing macrocyclic compounds

Intermediates of the formula QUIN: and methods for their preparation are described. The intermediate compounds are useful for preparing active agents for the treatment of hepatitis C virus (HCV) infection.

This invention discloses a novel method for the conversion of carboxylic acids to carbothioic acids and application of the method to the preparation of androstane carbothiolates, such as fluticasone propionate, which avoids column chromatography.

Method for the preparation of fluticasone and related 17&#x3b2;-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods

The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and a Lewis acid.

Process for producing 13-cis retinoic acid

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Lindenhurst, IL, United States of America

Azad Hossain