Cornell University

Tri-Institutional Therapeutics Discovery Institute

Ayumu Sato

Peter T Meinke

Rei Okamoto

Michael Andrew Foley

Jochen Buck

Lonny Levin

Timothy Hla

Yoshiyuki Fukase

Mayako Michino

Lavoisier Ramos-Espiritu

Clemens Steegborn

Irina Jilishitz

Hiroki Takahagi

Andrew Stamford

William J Polvino

Hideyuki Igawa

Asato Kina

Yasufimi Wada

The various examples presented herein are directed to compounds of the formula A-L-Het-L-Cyor a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Hetis heterocyclyl containing at least two heteroatoms; Cyis a heterocyclyl; Lis a bond, alkyl, alkenyl or alkynyl linker; Lis an acyl or alkyl linker; and A and Cyare different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

Pyridinone- and pyridazinone-based compounds and uses thereof

Provided are 6-amino substituted 2,6-diamino-4-chloropyrimidine compounds which are specific inhibitors of soluble adenylyl cyclase. The compounds can be formulated with pharmaceutical carriers and used for reducing cyclic AMP levels. The compositions can be used for treatment of various conditions including ocular hypotony.

Inhibitors of soluble adenylyl cyclase

Growing community of inventors

Zushi, Japan

Ayumu Sato