Eisai R&d Management Co., Ltd.

Ayumi Takemura

Toshiaki Tanaka

Taro Terauchi

Yu Yoshida

Yoshimitsu Naoe

Keiichi Sorimachi

Yuji Kazuta

Takashi Doko

Huiming Zhang

George Moniz

Jaemoon Lee

Farid Benayoud

Carsten T Beuckmann

Annie Zhu Wilcoxen

George Anthony Moniz

The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents &#x2014;CH&#x2014; or a nitrogen atom, Rand Reach independently represent a Calkyl group and the like, Rrepresents a hydrogen atom and the like, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, a Calkyl group and the like, R, Rand Reach independently represent a hydrogen atom, a halogen atom and the like, and Rrepresents a hydrogen atom and the like.

Cyclopropane compound

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Tsukuba, Japan

Ayumi Takemura