Mauna Kea Technologies

Institut National De Recherche En Informatique Et En Automatique

Aymeric Perchant

Nicholas Ayache

Francois Lacombe

Tom Vercauteren

Georges Le Goualher

Bertrand Viellerobe

Xavier Pennec

Nicolas Savoire

Gregoire Malandain

Frédéric Berier

Nicolas Boularot

Magalie Genet

François Lacombe

Francois Doussoux

Frederic Berier

Sandra Marti

Stéphane Bourriaux

François Doussoux

An endoscopy device includes several light guides (), each light guide having one or more optical fibers. The light guides are coupled with a sweeping system () arranged to direct an excitation light beam in alternation in one of the fibers of the guides from the proximal end of the guide including the one of the fibers. In this way, the proximal ends of the guides may make use of the same sweeping system, whereas the distal ends of the guides may be installed simultaneously in different zones of interest of an object or animal () under study for an almost simultaneous observation of the zones of interest. The invention also relates to an endoscopy method used in a device according to the invention. A device and a method according to the invention may be applied to quasi-simultaneous reflectance, fluorescence, multi-photon imaging of several areas of interest.

Endoscopy device and method for simultaneous observation of several zones of interest

A method to process an image acquired through an optical-fiber guide includes acquiring a first reference image through the optical-fiber guide, acquiring a second calibration image through the optical-fiber guide, spatially identifying each fiber of the optical-fiber guide of the second calibration image in a first detection map, acquiring a recalibration image through the optical-fiber guide, determining a geometrical transformation to make the recalibration image coincide with the first reference image, deriving a new detection map spatially identifying each fiber of the optical-fiber guide of the recalibration image, wherein the new detection map is derived using the geometrical transformation and the first detection map, and individually processing zones of an acquired image corresponding to each fiber of the optical-fiber guide using the new detection map.

Image processing method and apparatus

A method for processing images acquired in real time through a medical device, said images being loaded into a buffer, comprising the steps of: stopping the loading of the images into the buffer, processing loaded images using an incremental algorithm, displaying successively intermediate results of the processing, resuming the loading and stopping the processing based on an evaluation of said intermediate results.

Method and system for processing images acquired in real time through a medical device

A method for mosaicing frames from a video sequence is disclosed. Each frame is constituted by a point cloud, and each point in the point cloud is potentially acquired at a different time. The method involves compensating for motion and motion distortion due to acquisition time differences in each frame, applying a global optimization of inter-frame registration to align consistently the frames, and applying a reconstruction algorithm on the registered frames to construct a mosaic.

Robust mosaicing method, notably with correction of motion distortions and tissue deformations for a vivo fibered microscopy

A mosaicing method taking into account motion distortions, irregularly sampled frames and non-rigid deformations of the imaged tissue. The method for mosaicing frames from a video sequence acquired from a scanning device such as a scanning microscope, includes the steps of: a) compensating for motion and motion distortion due to the scanning microscope, b) applying a global optimization of inter-frame registration to align consistently the frames c) applying a construction algorithm on the registered frames to construct a mosaic, and d) applying a fine frame-to-mosaic non rigid registration. The method is based on a hierarchical framework that is able to recover a globally consistent alignment of the input frames, to compensate for the motion distortions and to capture the non-rigid deformations.

Robust mosaicing method, notably with correction of motion distortions and tissue deformations for in vivo fibered microscopy

The invention relates to a method for measuring the speed of a particle such as a red blood cell moving inside a flow such as a flow of the blood, using a light scanning microscope. The inventive method comprises the following steps: acquisition of an image by x and y light scanning on a plane containing the object; detection on the plane (x, y) of a mark on the plane (x, y); estimation of the speed vof the object from the gradient thus determined.

Method and system for measuring the speed of blood flow

A method for processing an image acquired through a guide consisting of a plurality of optical fibers includes, for each optical fiber, isolating on the acquired image a zone corresponding to the optical fiber, locally processing each zone individually to correct the photon flux detected in each optical fiber, then reconstructing the acquired image by eliminating the pattern caused by the optical fiber. The method also includes a sampling process for obtaining, for each optical fiber and from a sampling image, a sample injection rate which can be used for reconstructing the acquired images. The method also includes a prior step which consists in detecting the fibers from a target.

Method for processing an image acquired through a guide consisting of a plurality of optical fibers

A method for increasing the resolution of confocal images acquired through an image guide whereof the distal end is associated with an optical head for focusing the laser beam emitted by the image guide in an observation object. For a given position of the optical head, the method includes the following steps: producing a plurality of acquisitions through the image guide, each acquisition being produced for a specific spatial shift of the distal end of the guide image relative to the optical head which remains stationary; transforming the data of each acquisition into a point cloud; registering each scatter plot relative to a point cloud taken as reference; superimposing the thus registered point clouds; and reconstructing a final image from the superimposition. Advantageously, a controlled piezoelectric tube is used arranged about the distal end of the image guide to shift the latter.

Method and system for super-resolution of confocal images acquired through an image guide, and device used for implementing such a method

Equipment includes an image guide () consisting of flexible optical fibers with: on the proximal end side: a source (), angular scanning elements (), injection elements () in one of the fibers, elements for splitting () the illuminating beam and the backscattered signal, elements for spatial filtering (), elements for detecting () the signal, electronic elements () for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head () for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M) and a galvanometric field mirror (M) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M, M) firstly in the field mirror (M) and the injection elements () in the image guide in a second step.

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Fontenay Sous Bois, France

Aymeric Perchant