Eligo Bioscience

Aymeric Leveau

Antoine Decrulle

Aurélie Mathieu

Inès Canadas Blasco

Jesus Fernandez Rodriguez

Thibault Carlier

The invention relates tocarrying DNA vectors with aphage packaging signal and a gene of interest. The invention encompasses aproducer cell carrying DNA vectors, with aphage packaging signal and a gene of interest, for the production of phage-derived particles that can robustly transducereceiver cell allowing transgene expression. The invention encompassesphage-derived particles carrying these vectors,containing these vectors or modified by transduction of these phage-derived particles, and methods of using these phage-derived particles.

Phage-derived particles for in situ delivery of DNA payload into C. acnes population

The invention relates tostrains carrying DNA vectors for the production of recombinantphages. The invention encompasses aproducer cell carrying DNA vectors, with a template for recombination withphage genome leading to the insertion of a gene of interest, for the production of recombinant phages that can lead to the transgene expression intoinfected by the recombinant phage. The invention encompasses,strains containing these vectors,recombinant phages and methods of using these recombinant phages.

recombinant phages encoding a human protein

Phage-derived particles for in situ delivery of DNA payload intopopulation

The present invention concerns a production bacterial cell for producing lytic phage particles or lytic phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural genes and at least one phage DNA packaging genes, said phage structural gene(s) and phage DNA packaging gene(s) being derived from a lytic bacteriophage, wherein the expression of at least one of said phage structural genes and/or at least one of said phage DNA packaging gene(s) in said production bacterial cell is controlled by an induction mechanism.

Production of lytic phages

The present invention concerns a production bacterial cell for producing phage particles or phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural gene(s) and at least one phage DNA packaging gene(s), said phage structural gene(s) and phage DNA packaging gene(s) being derived from a first type of bacteriophage,

Production bacterial cells and use thereof in production methods

Recombinantphages comprising transgenes

The present invention concerns a production bacterial cell for producing lytic phage particles or lytic phage-derived delivery vehicles, said production bacterial cell stably comprising at least one phage structural genes and at least one phage DNA packaging genes, said phage structural gene(s) and phage DNA packaging gene(s) being derived from a lytic bacteriophage,

Growing community of inventors

Paris, France

Aymeric Leveau