Genset S.a.

Serono Genetics Institute S.a.

Genset

Merck Serono Biodevelopment

Aymeric Duclert

Jean-Baptiste Dumas Milne Edwards

Lydie Bougueleret

Jean-Yves Giordano

Catherine Clusel

Bruno Lacroix

Bernard Bihain

Frances Yen-Potin

Barbara Bour

Blake Denison

Dana Ebbets-Reed

Luisa Salter-Cid

Jean-Baptiste Dumas Milne-Edwards

The sequences of 5' ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5&#x2032; ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5&#x2032; ESTs. The 5&#x2032; ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5&#x2032; ESTs. The 5&#x2032; ESTs may also be used to design expression vectors and secretion vectors.

Expressed sequence tags and encoded human proteins

The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.

Methods and compositions for inhibiting neoplastic cell growth

The sequence of a cDNA encoding Claudin-50 and sequence of Claudin-50 protein are disclosed. The cDNA can be used to express the protein or portions thereof or to obtain antibodies capable of specifically binding to the secreted protein. The cDNA may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNA may also be used to design expression vectors and secretion vectors.

Antibodies to claudin-50 polypeptide

The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.

Complementary DNAs

The sequences of 5&prime; ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5&prime; ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5&prime; ESTs. The 5&prime; ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5&prime; ESTs. The 5&prime; ESTs may also be used to design expression vectors and secretion vectors.

The invention concerns CCRP-1 polynucleotides and polypeptides. The invention further relates to methods of directing polynucleotides, polypetides, and small molecules to mitochondria. The invention further relates to methods of reducing blood levels of fatty acids in an individual. The invention also concerns methods of identifying individuals who are at increased risk or who have a predisposition for developing, or present state of having, a diseases or disorder, such as obesity or heart disease, by determining the level of a CCRP-1 gene product in an individual.

Carnitine carrier related protein-1

Claudin-50 protein

The sequences of 5&prime; ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5&prime; ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5&prime; ESTs. The 5&prime; ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be otained using the 5&prime; ESTs. The 5&prime; ESTs may also be used to design expression vectors and secretion vectors.

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Saint-Maur, France

Aymeric Duclert