National Guard Health Affairs

King Saud Bin Abdulaziz University for Health Sciences

King Abdullah International Medical Research Center

King Abdulaziz City for Science and Technology

Ayman Mahmoud Saleh

Amre Osman Nasr

Mamoun Ahmad Salim Ahram

A plant-based composition containing an alcohol extract ofspecies (e.g.) and an exogenous carrier and/or excipient. Also provided is a composition including a mixture of three acids, namely corosolic acid, oleanolic acid, and ursolic acid, which can be found in thespecies. Methods of treating skin lesions (e.g. warts, corns, calluses, and umbilical granulomas) and reducing symptoms associated with the skin lesions using such compositions are specified.

Artificial compositions comprising corosolic acid, oleanolic acid; and ursolic acid in a form of an emulsion, salve, ointment, suspension, or gel

A method for isolating a protein complex comprising BCL10 and at least one, preferably all, of ROS1, LSD1, BTK, KU80, KU70, CUL4A, IMP3, thioredoxin, hTID1, DAP3, CDK1/CDC2, PRL1/PTP4A1 or NM23. Methods for using this complex to diagnose or prognose diseases including diabetes, obesity, cancer, neurodegenerative disease or inflammatory diseases associated with activation of NF-κB. Methods for distinguishing lean, obese and diabetic subjects based on expression of BCL10 and its ligands are also disclosed. The invention also pertains to pharmaceutical compositions comprising ligands for BCL10 or other components of this complex or agents such as siRNA or miRNA that regulate the expression of the protein components of this complex.

Purification and identification of a protein complex containing b-cell lymphoma protein (BCL10)

A pharmaceutical composition containing an anti-proliferative compound, named Tecomaphorbide, which is identified and isolated fromplants (e.g.). The pharmaceutical composition may contain a derivative and/or a salt of Tecomaphorbide. A process of obtaining Tecomaphorbide fromplants is specified. A method of treating cancer (e.g. leukemia, lymphoma, breast, colon, and prostate cancer) with the pharmaceutical composition is also provided.

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Jeddah, Saudi Arabia

Ayman Mahmoud Saleh