The United States of America, as Represented by the Secretary, Department of Health and Human Services

Georgetown University

University of Massachusetts

St. Vincent's Institute of Medical Research

Aykut Üren

Jeffrey S Rubin

Jeffrey A Toretsky

Milton L Brown

Yali Kong

Susan Cumberledge

Frieda Reichsman

Matthew Todd Gillespie

Nicole Joy Horwood

Brian K Kay

Bernard Weisblum

Haydar Celik

Milton Lang Brown

Provided herein are methods of treating a bone or connective tissue cancer in a subject. The methods comprise administering to the subject an effective amount of a CD99 inhibitor, wherein the CD99 inhibitor is a compound having the formula  wherein R, each of which may be the same or different, is hydrogen, or a protecting group; wherein Z is selected from the group consisting of F, Cl and Br; wherein X is H or F; and pharmaceutically acceptable salts thereof.

CD99 inhibitors and their uses

Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

Targeting of EWS-FLI1 as anti-tumor therapy

This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.

sFRP and peptide motifs that interact with sFRP and methods of their use

The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.

Fragments of secreted frizzled related protein

SFRP and peptide motifs that interact with SFRP and methods of their use

Secreted frizzled related protein fragments

Growing community of inventors

Rockville, MD, United States of America

Aykut Üren