Georgetown University

National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Massachusetts

St. Vincent's Institute of Medical Research

Kay, Brian K.

Weisblum, Bernard

Aykut Uren

Milton L Brown

Jeffrey A Toretsky

Jeffrey S Rubin

Yali Kong

Susan Cumberledge

Frieda Reichsman

Perrer N Tosso

Brian K Kay

Mikell Paige

Bernard Weisblum

Jeffrey A Torestsky

George Kosturko

Gullay Bulut

Nicole Joy Horwood

Matthew Todd Gillespie

Milton Lang Brown

Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

Targeting of EWS-FLI1 as anti-tumor therapy

Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

Methods and compositions for treating Ewings sarcoma family of tumors

The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.

Ezrin inhibitors and methods of making and using

Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.

Methods and compositions for treating cancer

The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.

Methods of use of fragments of secreted frizzled related protein, sFRP

Secreted frizzled related protein, sFRP, fragments and methods of use thereof

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Rockville, MD, United States of America

Aykut Uren