The United States of America, as Represented by the Secretary, Department of Health and Human Services

Biocompatibles UK Limited

Biocompatible UK Limited

Ayele H Negussie

Bradford Johns Wood

Matthew R Dreher

Yiqing Tang

Andrew Lennard Lewis

Hugh Britton

Jonathan Vince

Andrew Leonard Lewis

This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.

Imageable embolic microsphere

Described herein are X-ray imageable polymers such as polymeric particles comprising bismuth as a radiopacifying agent, methods of making the polymers, and methods of using the polymers. The imageable particles may comprise a covalently bound compound which chelates the bismuth, for example, through a combination of nitrogen and oxygen atoms.

Imageable polymers, methods of making and methods of use thereof

Cyclized peptide compounds containing the NGR motif of formula (I) or a pharmaceutically-acceptable salt thereof are disclosed. Compositions comprising the cyclized peptide compounds and methods of their use are also disclosed. 

Cyclized NGR peptide compounds, compositions, and methods of their use

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Bethesda, MD, United States of America

Ayele H Negussie