Kikkoman Corporation

Ayako Nasu

Riichiro Uchida

Nobuyuki Yamaji

Shigehiro Kataoka

Koichiro Tobe

Motohiko Kato

Yukihiko Iwai

Takao Someya

The present invention provides a substance which strongly inhibits human &#x3b1;-amylase and is effective for the prevention and treatment of hyperglycemia, for example, diabetes and the diseases caused thereby, and an &#x3b1;-amylase inhibitor and a prophylactic or therapeutic agent for hyperglycemia containing the said substance as active principle. Maltoligosaccharide derivatives represented by the following formula:(wherein n is an integer of 0 to 2; m is an integer of 0 to 2; and X represents a hydrogen atom or a hydrophobic group) or their hydrates or physiologically acceptable salts are provided, and they are contained as active principle to prepare an &#x3b1;-amylase inhibitor and a prophylactic or therapeutic agent for hyperglycemia such as diabetes.

Malto-oligosaccharide derivatives and use thereof

Malto-oligosaccharide derivatives and uses thereof

A method for the preparation of an N.sup.6 -substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein R.sub.1 represents a straight chain or branched chain alkyl group of 1 to 13 carbon atoms or an aromatic group and B.sym. represents a hydrogen ion or an alkali metal ion, which comprises allowing a 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR2## wherein A.sym. represents a hydrogen ion, alkali metal ion, organic ammonium ion, or ammonium ion, to react with an aldehyde represented by the general formula

Process for preparation of N.sup.6 -substituted 3',5'-cyclic adenosine

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Noda, Japan

Ayako Nasu