Kyorin Pharmaceutical Co., Ltd.

Nikon Corporation

Teijin Pharma Limited

Ayako Nakamura

Yasumichi Fukuda

Masahiro Nomura

Anna Katrin Szardenings

Shigeki Seto

Bei Li

Kyoko Okada

Kazuhiro Yumoto

Oana Cociorva

Yasushi Kohno

Katrin Szardenings

Shinji Kobayashi

Masanori Yamamoto

Kenji Fujita

Hiroshi Ooki

Masahiro Nakagawa

Yoshikazu Asahina

Tatsuo Fukui

Tomohiro Ide

Fumiyoshi Kobayashi

Kanji Komatsu

Yasmuchi Fukuda

There is provided an optical characteristic measuring method for measuring an optical characteristic of an optical system which forms, on a second plane, an image of an object arranged on a first plane, the optical characteristic measuring method including: arranging, on the first plane, a first area through which a measuring light passes or by which the measuring light is reflected; arranging a second area, through which the measuring light passes or by which the measuring light is reflected, on the second plane at a position corresponding to the first area; and detecting, via one of the first area and the second area, a light amount of the measuring light via the optical system and the other of the first area and the second area; wherein at least one of the first area and the second area has a shape such that a light amount, of the measuring light which passes or which is reflected via the optical system, is changed depending on the optical characteristic.

Optical characteristic measuring method, optical characteristic adjusting method, exposure apparatus, exposing method, and exposure apparatus manufacturing method by detecting a light amount of measuring light

Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases.

Spirocyclic aminoquinolones as GSK-3 inhibitors

Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases. In Formula (I): Xis O or NR; A is bond or substituted or unsubstituted C-Calkylene, wherein the substituents when present are selected from one to four Qgroups; where Qis alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2. 

A compound represented by the following formula (1): (wherein the carbon atom denoted by * is in the R-configuration; Rand Rare each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C-Calkyl group, a C-Calkoxy group, a C-Calkylsulfanyl group, a C-Calkylsulfinyl group or a C-Calkylsulfonyl group; and A is a substituted or unsubstituted heteroaryl group), or a pharmaceutically acceptable salt thereof.

Glucokinase activator

Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.

Aminoquinolones as GSK-3 inhibitors

A position detection apparatus for and method of detection the position of a pattern formed on a substrate (e.g, a wafer). The apparatus ( ) comprises an illumination system capable of illuminating the pattern, and an imaging optical system arranged to converge light from the substrate ( ) to form an image of the pattern. The apparatus further includes a detector ( ) that photoelectrically detects the pattern image and generates a first output signal containing a representation of the image, and position detection system ( ), electrically connected to the detector, that detects a position of the pattern based on the first output signal, and determines a deviation of the position from an ideal position. The position detection system then generates a second output signal containing deviation information representing the deviation. The apparatus further comprises a memory unit (M), electrically connected to the position detection system, that stores the deviation information contained in the second output signal. Further included in apparatus is a correction process unit (B), electrically connected to the memory unit, that generates a correction value for eliminating the deviation based on the deviation information.

Position detection apparatus and method

Growing community of inventors

Shimotsuga-gun, Japan

Ayako Nakamura