Nitto-Denko Corporation

Isis Pharmaceuticals, Inc.

Ayako Matsunawa

Tatsuya Konishi

Vasulinga T Ravikumar

Gang Zhao

Raju K Kumar

Takeo Matsumura

Kenjirou Mori

Cheiko Kitaura

Kenjiro Mori

The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.

Polymeric beads for oligomer synthesis

The present invention provides, as a resin bead which can be developed for use completely different from the use of conventional polystyrene resin beads, a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contain a hydroxyl group in an amount of 10&#x2013;1000 &#x3bc;mol/g, and further, a production method of a porous resin bead made from a styrene-hydroxystyrene-divinylbenzene copolymer, which contains suspension copolymerization of a styrene monomer, an acyloxystyrene monomer and a divinylbenzene monomer using an organic solvent (containing at least hydrocarbon and alcohol) and water, followed by hydrolysis reaction.

Porous resin bead production method

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Osaka, Japan

Ayako Matsunawa