Sawai Pharmaceutical Co., Ltd.

Ayako Harada

Kenji Nozawa

Hiroaki Kikuoka

Wataru Izui

Yoichi Higashiyama

Satoru Ogihara

Provided is a novel additive for an orally disintegrating tablet which imparts a rapid disintegration property and a tablet hardness to the orally disintegrating tablet and a method for producing the same. An additive for an orally disintegrating tablet according to one embodiment of the present invention includes a D-mannitol, a low-substituted hydroxypropyl cellulose (excluding those having a mean particle size of 20 &#x3bc;m or less and a substitution degree of the hydroxypropoxy groups of 11%, having a mean particle size of 45 &#x3bc;m or less and a substitution degree of the hydroxypropoxy groups of 14% and having a mean particle size of 45 &#x3bc;m or less and a substitution degree of the hydroxypropoxy groups of 11% together with a 90% cumulated particle size of 100 &#x3bc;m or less), a crospovidone and a crystalline cellulose.

Additive composition for orally disintegrating tablet

Provided is a novel additive for an orally disintegrating tablet providing quick disintegrability and tablet hardness to the orally disintegrating tablet, and a producing method therefor. According to an embodiment of the present invention, there is provided an additive for an orally disintegrating tablet characterized by including D-mannitol, low-substituted hydroxypropyl cellulose (however, excluding the low-substituted hydroxypropyl cellulose having a mean particle size of 20 &#x3bc;m or less and a substitution degree of hydroxypropoxy groups of 11%, a mean particle size of 45 &#x3bc;m or less and a substitution degree of hydroxypropoxy groups of 14%, and a mean particle size of 45 &#x3bc;m or less and a substitution degree of hydroxypropoxy groups of 11% and a 90% cumulated particle size of 100 &#x3bc;m or less), crospovidone, and microcrystalline cellulose, wherein the low-substituted hydroxypropyl cellulose and the crospovidone are included in a ratio of 5:4.

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Osaka, Japan

Ayako Harada