Sanofi-aventis

Mitsubishi Pharma Corporation

Mitsubishi Tanabe Pharma Corporation

Sanofi-synthelabo

Mitsubishi Chemical Corporation

Aya Shoda

Kazutoshi Watanabe

Fumiaki Uehara

Ryoichi Ando

Masahiro Okuyama

Yoshihiro Usui

Shinsuke Hiki

Keiichi Aritomo

Jonathan Reid Frost

Adrien Tak Li

Mitsuru Ooizumi

Keiichi Arimoto

Antonio Almario Garcia

Kenji Fukunaga

Toshiyuki Kohara

Ken-ichi Saito

Satoshi Yokoshima

Rie Kawamoto

Koichi Yamakoshi

Antonio Almario Carcia

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein Rrepresents a C-Calkyl group which may be substituted;R represents, for example, a group represented by the following formula (II): wherein Rand Rindependently represent a hydrogen atom or a C-Calkyl group;Rrepresents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.

3-Substituted-4-pyrimidone derivatives

A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C-Calkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C-Calkyl group, an optionally partially hydrogenated C-Caryl ring, an indan ring or the like; m represents an integer of 1 to 3; each independently represents a halogen atom, a hydroxy group, a cyano group, a C-Calkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C-Calkylene group. 

2,3,6-Trisubstituted-4-pyrimidone derivatives

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein Rrepresents a C-Calkyl group which may be substituted; R represents, for example, a group represented by the following formula (II): wherein Rand Rindependently represent a hydrogen atom or a C-Calkyl group; Rrepresents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total. 

3-substituted-4-pyrimidone derivatives

A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3&#x3b2; such as Alzheimer's disease.

2-amino-3-(alkyl)-pyrimidone derivatives

A pyrimidone derivative represented by the formula (I) or a salts thereof: wherein Rrepresents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; Rrepresents a hydrogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like, Rrepresents a pyridyl group, and a medicament comprising said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as Alzheimer disease.

Pyrimidone derivatives

A pyrimidone derivative represented by formula (I) or a salt thereof: And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3&#x3b2; such as Alzheimer's disease.

2-amino-3-(alkyl)-pyrimidone derivatives as GSK3.&#x3b2;.inhibitors

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Tokyo, Japan

Aya Shoda