Bayer Aktiengesellschaft

Axel Wollenschlager

Heiko Herold

Alfred Von Schuckmann

Roland Rupp

Josef Schmoll

Andreas Ohm

Manfred Bucheler

Franz Schmitt

Reiner Diederich

Roland Kleissendorf

Matthias Herboth

Harald Landen

Ahmed Hegazy

The precipitation system comprises a collection tube (1) which can be fitted onto the powder inhaler with a mouthpiece (3) and a centrifugal precipitator (2,6) arranged in the collection tube (1). This centrifugal precipitator has at least one spin-producing surface (2) which produces a spin flow in the collection tube (1), as a result of which the heavy coarse powder particles are precipitated on the inner wall of the collection tube (1) while the lighter fine powder particles pass into the mouthpiece (3) due to a flow which is essentially restricted to the area surrounding the tube axis.

Precipitation system for a powder inhaler

Nasal applicators are an important aid for introducing powdery, pharmacologically active medicaments into the nasopharyngeal space of a patient. The present nasal applicator is based on a manually actuated compressed air source connected to an inflow channel (8) for generating a compressed air jet, a storage container (3) for the medicament and a metering device for making available a portioned-off quantity of the medicament which is caught by the compressed air jet and transported through an outflow channel (9) into the nose. The metering device consists of a metering drum (5) in which the storage container (3) for the medicament is formed by the interior of the metering drum (5). In addition, the inflow channel (8) is connected to one end of a metering channel (7) and the outflow channel (9) to the other end of the metering channel (7). The quantity of medicament made available in one portioning chamber (13) of the metering drum (5) protrudes into the metering channel (7) in such a manner that it is completely caught by the compressed air jet and transported into the nasal cavities.

Nasal applicator

The device for inhalation of a powdery, pharmacologically active drug consists of a supply container (3) for the drug (4), a manually actuated metering unit for providing a portioned-off quantity of inhalation substance which is picked up by the air current drawn in during inhalation and is swirled, an air inlet channel (9), a swirl chamber (W), and a connection channel (8) between the swirl cheer (W) and the metering unit, as well as a mouthpiece channel issuing from the swirl chamber (W). The metering unit here consists of a metering drum (D) which has, in its interior (5), a supply container (3) for the drug. Furthermore, the air inlet channel (9) and the connection channel (8) are arranged in such a way that they run towards each other in a V-shape. During a metering procedure, a portioned-off quantity of drug for inhalation present in the shape of a dome is provided in each case at the apex of the two air channels (8) and (9) running towards each other in a V-shape.

Device for inhalation

The powder inhaler is based on a supply container (3) for the drug, which supply container is partially or completely closed off at its lower end by a rotatable or displaceable, manually actuated metering plate (4) for the repeated reception and delivery of a predetermined, reproducible quantity of the drug from the container (3), and of a mouthpiece (14) for inhaling, upstream of which a dispersing chamber (12) is connected. The metering plate (4) is provided with at least one depression (5) which is filled with the drug on actuation of the inhaler. Seen in the flow direction, an acceleration channel is arranged ahead of the dispersing chamber (12), which acceleration channel (8) partially covers the metering plate (4) with part of its longitudinal surface and opens out tangentially into a cylindrical dwell-time chamber (9). The dwell-time chamber (9) is, in turn, connected via a central outlet (10) of smaller diameter than the cylindrical dwell-time chamber (9) to a circular discharge chamber (11 ) which the dispersing chamber ( 12) adjoins tangentially.

Powder inhaler having dispersing, discharge, and dwell-time chambers,

Controlled release medicament pellets comprising

Growing community of inventors

Bergisch Gladbach, Germany

Axel Wollenschlager