Behringwerke Aktiengesellschaft

Axel Sieber

Norbert Heimburger

Arno Holst

Helmut Lask

Horst Schwinn

Wolfgang Kapmeyer

Jurgen Gross

A process for the detection and for the determination of immunocomplexes in liquids is described. It is based on determining the rate at which the immunoglobulin or the antigen present in the complex reacts with an appropriate immuno-partner, and relating this rate to the rate at which this immunoglobulin or antigen reacts with the corresponding immuno-partner in an immunocomplex-free liquid.

Process for the kinetic determination of immunocomplexes

What is disclosed is an improved nephelometric method for detecting an antigen or antibody by contact thereof in a liquid medium with particles of a latex reagent comprising latex particles of different sizes loaded with different amounts of a corresponding antibody or antigen and then measuring the light scattered by a latex reagent.

Latex reagent

A bond is produced between a synthetic polymer containing vicinal hydroxyl groups and a substance containing primary amino groups by treating the polymer with a medium to strong oxidant until a sufficient number of aldehyde groups is formed and then reacting the oxidation product with the substance containing primary amino groups.

Process for producing a bond between polyvinylene glycol and a substance

Lyophilized blood plasma under a protective gas wherein the protective gas contains at least 5% of carbon dioxide.

Stable blood plasma, process for preparing it and its use as comparative

Antigen-antibody reactions are measured by passing laser light through the mixture of the antigen solution with the corresponding antibody and measuring the light scattered in the forward direction and determining its intensity. The device used comprises a measuring system consisting of a laser, at least two diaphragms, a system of lenses and a photodetector and a light trap having a diameter corresponding to 1.1 to 1.7 times the diameter of the laser beam.

Process and device for measuring antigen-antibody reactions

An arrangement for the simultaneous qualitative or quantitative determination of several antigens in mixtures of antigens by immunoelectrophoresis in a matrix containing antibodies, by coating the support for the matrix with several matrix strips, one following the other and each containing a specific antiserum, and a process for the determination of several antigens in mixtures, wherein said arrangement is used.

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Marburg-Marbach, Germany

Axel Sieber