Ipf Pharmaceuticals Gmbh

Axel Schulz

Wolf-Georg Forssmann

Frank Kirchhoff

Jan Münch

Knut Adermann

The invention relates to peptides with biological activity against infection having the amino acid sequence Z-LE-X-IP-X-X-X-P-X-X-X-X-X-X-K-X-X-X-X-X-Z, wherein Xis a lysine, alanine, or aspartic acid; Xis a cysteine, methionine or isoleucine; Xis a serine, cysteine, lysine or glycine; Xis an isoleucine, alanine, phenylalanine or cysteine; Xis a proline, D-proline or a substituted L- or D-proline; Xis a cysteine or glutamic acid; Xis an amino acid with a hydrophobic or an aromatic side chain or cysteine; Xis an amino acid with a hydrophobic or an aromatic side chain or cysteine; Xis an amino acid with an aromatic side chain; Xis a glycine, alanine or asparagine; Xis a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Xis a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Xis an amino acid with a hydrophobic or an aromatic side chain; Xis an amino acid with a hydrophobic or an aromatic side chain; Xis a phenylalanine or deletion; Zis NHor a sequence of 1 to 10 amino acid residues; Zis COOH or a sequence of 1 to 10 amino acid residues; and peptides which are fragments and/or covalently linked oligomers and/or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and/or glycosylated derivatives, and mutants thereof, and with the provisio that (a) if Xis alanine, glycine, glutamic acid, or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid than X, Xand Xare phenylalanine, valine and phenylalanine respectively; and/or (b) if Xis phenylalanine, than X, Xand Xare valine, phenylalanine and a deletion, respectively; and (c) that there are at maximum two cysteine residues in a peptide.

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Hannover, Germany

Axel Schulz