California Institute of Technology

University of Southern California

The Boeing Company

Dartmouth College

Other

Sanofi

USA as Represented by Secretary of the Navy

Nichia Corporation

Apic Corporation

University of California

Cantrele Telecom Co., L.l.c.

Axel Scherer

Aditya Rajagopal

Stephen R Quake

Sameer Walavalkar

Hou-Pu Chou

Todd A Thorsen

Marc Alexander Unger

Emil Paskalev Kartalov

Andrew Peter Homyk

George Maltezos

Xiomara Linnette Madero

Michael David Henry

Samson Chen

Imran R Malik

Erika F Garcia

Thomas Anthony Tombrello, Jr

Chieh-feng Chang

Michael J Hochberg

Carl L Hansen

Christopher I Walker

Demetri Psaltis

Tom Baehr-Jones

Jeremy Witzens

Changhuei Yang

Lawrence Cary Gunn, Iii

Scott E Fraser

Amnon Yariv

Peter Albert Petillo

Xiquan Cui

William M Jones

Xin Heng

John O'Brien

Frank Thomas Hartley

Mladen Barbic

Stefan Petry

Oskar Jon Painter

Oliver Plettenburg

Harold E Hager

Clive R Taylor

W French Anderson

Yong Xu

Guoan Zheng

Isamu Niki

Yoichi Kawakami

Harry A Atwater

Eric Y Chan

Brandon C Marin

Leora Peltz

Azita Emami

John K Liu

Sameer Sudhir Walavalkar

Muhammad Mujeeb-U-Rahman

Mark L Adams

Seheon Kim

Taeyoon Jeon

Muhammad Musab Jilani

Samuel Njoroge

Markus M Enzelberger

Jingqing Huang

Mark D Goldberg

Arti Gaur

Meisam Honarvar Nazari

Dvin Adalian

Matthew Johnston

David Goodwin

Deepan Kishore Kumar

Marko Loncar

Mehmet Sencan

Amirhossein Nateghi

Theodore Doll

William P Krug

Akram Sarwat Sadek

William Dos Santos Fegadolli

Jelena Vuckovic

Charles L Tschirhart

Thai Viet Truong

Shigeo Fujita

Koichi Okamoto

Yukio Narukawa

Jian Liu

Sheel Mukesh Shah

Zhenyu Li

Mitsuru Funato

John B Gorman

Jean-Jacques P Drolet

Michael J Shearn

Koichi Sayano

Reginald Lee

David T Wei

Michael C Hamilton

Yuanjian Xu

Meisam Honavar Nazari

Larry Dalton

Joyce Wong

Dong Yoon Oh

Kaushik Bhattacharya

Guruswami Ravichandran

Andrea R Tao

Jocelyn Y Takayesu

Thomas Y Hoffman

Methods and devices including implantable micro-sensors used to detect tissue-dissolved inert gas and to detect microbubble formation to avoid Caisson disease are described. The disclosed methods and devices are based on measuring the refractive index changes in hydrophobic liquids after absorbing an inert gas such as nitrogen. The changes in the refractive index are based on implementing one of an interferometry, optical microcavity resonance shift, a photonic crystal resonance, a beam deflection, a resonance tuning or detuning, an amplitude change, or an intensity change method.

Implantable micro-sensor to quantify dissolved inert gas

The teachings of the present disclosure enable a reduction of the refractive index of a material by incorporating an additive selected from air, vacuum, or an inert gas in the material to turn the material into a material foam that is suitable for use in optical systems. A material foam in accordance with the present disclosure is characterized by a porosity that reduces its refractive index from that of the same material as found in nature. The higher porosity also decreases the density of the material from that of the same material as found in nature. Material foams in accordance with the present disclosure are suitable for use in the low-refractive-index layers of a Bragg mirror.

Optical layer having a low refractive index and methods of fabrication

Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.

Canary on a chip: embedded sensors with bio-chemical interfaces

This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

Signal encoding and decoding in multiplexed biochemical assays

A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

System and methods for wireless drug delivery on command

A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

Method of producing thin enzyme-based sensing layers on planar sensors

Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.

Multiplexing and quantification in PCR with reduced hardware and requirements

An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.

Low power, chemically amplified, electrically removable barrier

A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.

Switchable low voltage electrochemical sensing for interfering species rejection

A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.

Chromophore-based detection of genetic variations in analytes

An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

Optical resonator diagnostic device and methods of use

A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.

Wireless automated animal monitoring system

Growing community of inventors

Laguna Beach, CA, United States of America

Axel Scherer