Klinge Pharma Gmbh

Lts Lohmann Therapie-systeme Gmbh + Co. Kg

Thomas Hille

Hans-rainer Hoffmann

Gerhard Schneider

Axel Knoch

Hans-joachim Huber

Fritz Stanislaus

Hans-Rainer Hoffmann

Hans-Joachim Huber

Josef M Hofer

Friedrich Stanislaus

The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a backing layer which is impermeable to active substances, an active substance deposit comprising at least one auxiliary agent with supporting and distributing function in the form of a textile fabric material, a matrix surrounding said deposit from all sides, and optionally a removable protective layer, the matrix of which comprises 10-90%-wt polymeric material selected from the group consisting of polymers on the basis of acrylate and/or methacrylate and esters of hydrogenated colophonium, 0-30%-wt softener on the basis of hydrocarbons and/or esters, and that the active substance deposit immediately after its production comprises 15-85%-wt of a 0.1-70%-wt physostigmine solution.

Transdermal therapeutical system with physostigmine as active component

Sprayable pharmaceutical preparations with an arylalkanoic acid or its salts as the active agent, suitable for topical application, containing as solvent a mixture of one or more volatile solvents and one or more non-volatile solvents in the weight ratio range of 1:1 to 20:1. They are especially suitable for the treatment of traumatic and rheumatic diseases.

Sprayable pharmaceutical composition for topical use

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Munich, Germany

Axel Knoch