Endress+hauser Conducta Gmbh+co. Kg

Endress+hauser Conducta Gesellschaft Fur Mess- Und Regeltechnik Mbh+co. Kg

Axel Fikus

Michael Hanko

Detlev Wittmer

Torsten Pechstein

Angela Eubisch

Lothar Auerswald

Dirk Steinmueller

Stefanie Honncher

Wilfried Hammelehle

Stefanie Jahn

Dirk Steinmüller

A method for automated in situ determining an analyte content of a liquid sample by means of a bioanalyzer, wherein a measurement duct has at least one substrate, comprising a repeatedly performable sequence of steps as follows: (i) preparing a sensor matrix, which has a plurality of receptors, which bind the analyte and/or a further target molecule, or bring about a chemical conversion of the analyte or of the further target molecule, leading through the measurement duct a preparation solution of at least a first chemical species, wherein a plurality of the first chemical species are bound on the substrate via the functional group binding on the substrate, wherein the other functional group of the plurality of the first chemical species bound on the substrate serves as a receptor or for subsequent binding of a receptor; (ii) leading the liquid sample, through the measurement duct, wherein analyte contained in the liquid sample or in the liquid to be measured, and/or other target molecules contained in the liquid sample or the liquid to be measured, bind, preferably selectively and specifically, on the receptors or are chemically converted by the receptors, and determining a measured variable correlated with the amount of the target molecules bound or converted by the receptors, and deriving therefrom the analyte content of the liquid sample; and (iii) regenerating, especially clearing, the at least one substrate, wherein the sensor matrix and, in given cases, molecules bound thereto, especially analyte molecules, other target molecules or other molecules, are released from the substrate and/or at least partially decomposed.

Method for determining an analyte content of a liquid sample by means of a bioanalyzer

A system for treating liquids, comprising: especially for analysis and/or synthesis of liquids, a fluidics unit having at least one functional unit; at least one liquid storage unit of the first type; at least one liquid storage unit of second type; a first liquid line; and a second liquid line, wherein a flow of liquid through the first liquid line directed from the fluidics unit to the liquid storage unit of first type is blocked, at least at times, by means of a first valve, and a flow of liquid through the second liquid line in the direction from the liquid storage unit of second type to the fluidics unit is blocked, at least at times, by means of a second valve.

System for treating liquids

A system for treating liquids comprising: a fluidics unit having at least one functional unit; at least one liquid storage unit of the first type; at least one liquid storage unit of second type; a first liquid line; and a second liquid line, wherein a flow of liquid through the first liquid line directed from the fluidics unit to the liquid storage unit of first type is blocked, at least at times, by means of a first valve and a flow of liquid through the second liquid line in the direction from the liquid storage unit of second type to the fluidics unit is blocked, at least at times, by means of a second valve.

A method for monitoring the functioning of sensors for the measurement and monitoring of state parameters of liquids or gases, especially in the field of process measurement technology, for example of electrochemical, electrophysical or optical sensors, wherein the sensor is placed into a test state at time intervals and test parameters are registered, or these test parameters are registered at time intervals in the course of the measured value registration. The registered parameters are stored and a backwards-looking, chronological development of the stored test parameters is evaluated for performing the functional monitoring and the development of sensor behavior to be expected in the future is predicted therefrom and information concerning the duration of the remaining, disturbance-free operation of the sensor is obtained.

Method for monitoring sensor function

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Hartha, Germany

Axel Fikus