Ebr Systems, Inc.

Pharmasonics, Inc.

Cardiovascular Imaging Systems, Inc.

Cardiac Pathways Corporation

Scimed Life Systems, Inc.

Hearing Innovations Incorporated

Axel F Brisken

Mark W Cowan

Debra S Echt

Richard E Riley

N Parker Willis

Paul W Mohr

David F Moore

Robert F Zuk

John R McKenzie

Robert Fowler

Paul Douglas Corl

Yue-Teh Jang

Michael Pare

James Brennan

Vartan E Ghazarossian

Jinglin Zeng

Marsha Kaye Hurd

Menahem F Nassi

Veijo T Suorsa

Christopher M H Newman

Nathaniel Parker Willis

Parker N Willis

Jeff Isner

Meno Nassi

Michael D Rold

Aage Gronningsaeter

Douglas A LaPorte

Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.

Implantable wireless acoustic stimulators with high energy conversion efficiencies

The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.

Methods and systems for heart failure prevention and treatments using ultrasound and leadless implantable devices

A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.

Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.

Optimizing energy transmission in a leadless tissue stimulation system

Implantable wireless accoustic stimulators with high energy conversion efficiencies

A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue. Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau. Based on this ratio, the controller-transmitter uses a measured query spike voltage to estimate the output voltage delivered by the receiver-stimulator to tissue.

Method and systems for heart failure prevention and treatments using ultrasound and leadless implantable devices

Systems and methods are disclosed to stimulate tissue to treat medical conditions involving tissues such as the bone, spine, stomach, nerves, brain and the cochlea. The disclosed invention uses electrical stimulation of the tissue, where vibrational (or acoustic) energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined tissue sites. The vibrational energy is generated by a controller-transmitter, which could be either implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located at or close to the stimulation site.

Systems and methods for implantable leadless tissue stimulation

Method of manufacturing implantable wireless acoustic stimulators with high energy conversion efficiencies

Methods and systems for heart failure treatments using ultrasound and leadless implantable devices

Growing community of inventors

Fremont, CA, United States of America

Axel F Brisken