Sanofi

Sanofi-aventis

Axel Dietrich

Dieter Kadereit

Karl Schoenafinger

Stephanie Hachtel

Matthias Schaefer

Thomas Huebschle

Katrin Hiss

Andreas Gille

Elisabeth Defossa

Stefanie Keil

Dieter Schmoll

Johanna Kuhlmann-Gottke

Karl-Christian Engel

Johanna Kuhlmann

The invention relates to oxazolopyrimidine compounds of formula I, where A, Rand Rare defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing. 

2,5-substituted oxazolopyrimidine derivatives

The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R, R, Rand X are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring

The invention relates to oxazolopyrimidine compounds of formula (I), where A, R, R, R, R, X and Y are defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing. 

Heterocyclic carboxylic acid derivatives having a 2,5,7-substituted oxazolopyrimidine ring

Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonists The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R, R, R, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring

The invention relates to oxazolopyrimidine compounds of formula (I), where A, R, Rand Rare defined as stated in the claims. The compounds of formula (I) are suitable, for example, for wound healing. 

2,5,7-substituted oxazolopyrimidine derivatives

The invention relates to oxazolopyrimidine compounds of formula (I), where A, R, R, R, Rand X are defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing. 

Carboxylic acid derivatives having a 2,5,7-substituted oxazolopyrimidine ring

The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.

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Frankfurt am Main, Germany

Axel Dietrich