Genomatica, Inc.

Dsm IP Assets B.v.

Verenium Corporation

Basf Enzymes LLC

Axel Christoph Trefzer

Stefaan Marie Andre De Wildeman

Marco Alexander Van Den Berg

Liang Wu

Petronella Catharina Raemakers-Franken

Martin Schurmann

Gerhard Johann Frey

Katie Kline

Brian Steer

Alberto Alvarado

Mark Dycaico

Arne Solbak

Fatima El-Farrah

Tom Todaro

Tomas Todaro

Stefaan Marie André De Wildeman

The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.

Adipate (ester or thioester) synthesis

The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as '6-ACA') using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as 'caprolactam') by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.

Preparation of 6-aminocaproic acid from 5-formyl valeri C acid

This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The phytases of the invention can be thermotolerant and/or thermostable at low temperatures, in addition to higher temperatures. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like. In one aspect, phytases of the invention are stabile against thermal denaturation during pelleting; and this decreases the cost of the phytase product while maintaining in vivo efficacy and detection of activity in feed.

Phytases, nucleic acids encoding them and methods for making and using them

Preparation of 6-aminocaproic acid from 5-formylvaleric acid

Growing community of inventors

Leidschendam, Netherlands

Axel Christoph Trefzer