Baxter International Inc.

American Hospital Supply Corporation

Baxter Travenol Laboratories, Inc.

Baxter Travenol

Ami-med Corporation

Campbell, Todd D.

Nashef, Aws S.

Aws Nashef

Sophie Carpentier

Alain Carpentier

Keith Myers

Rodolfo C. Quijano

Aws S Nashef

Alain F Carpentier

Sophie M Carpentier

Todd D Campbell

Than Nguyen

David W Wieting

R C Quijano

Denis Lee

Amir H Abolfathi

Ahmed I Ahmed

Rodolfo C Quijano

Keith E Myers

Said S Hilal

Ronald Dieck

Samer Abdel-Malik Nashef

Yassir Kamel Abdul-Hafiz

Dilation restrictor apparatus for use in conjunction with prosthetic vascular grafts, including venous valve grafts made from preserved bioprosthetic venous valves. The dilation restrictors limit the extent to which a blood vessel may dilate adjacent to a point whereat a cut end of the blood vessel has been anastomosed to an implant graft. Also disclosed is a related method of anastomosing the prosthetic graft to an existing vein segment of a patient.

Stent devices and support/restrictor assemblies for use in conjunction

Exovascular and endovascular stent devices and associated support/restrictor assemblies for use in conjunction with prosthetic vascular grafts, including venous valve grafts made from preserved bioprosthetic venous valves. Also disclosed are methods for preparing vascular grafts such as venous valve grafts using the devices and assemblies of the present invention.

Vascular and venous valve implant prostheses

A fluid volume flow monitoring apparatus, fluid volume flow monitoring system and process of monitoring fluid volume flow are disclosed. The fluid volume flow monitoring apparatus includes a support member having a distal end, a proximal end, and an outer wall with a first temperature sensing means for sensing fluid temperature positioned on the support member outer wall. A second temperature sensing means is positioned apart from the first temperature sensing means and juxtaposed to a generally tubular heat transfer device which is radially disposed about the support member outer wall. The heat transfer device directly contributes to the ability of the monitor to determine continuously fluid volume flow and includes an electrically insulated heating means positioned between a temperature equilibrator and an insulating material.

Apparatus and method for continuous cardiac output monitoring

A biological valvular prosthesis defined by a chemically fixed biological derived conduit having at least one integrally formed tissue valve. The chemical fixation of the valve ensures that the leaflets remain open under normal forward blood flow conditions, but close under minimal backflow pressure. The biological valvular prostheses are useful in the replacement of venous valves and other biological valves. The biological valvular prosthesis may also be in the form of a tubular conduit bearing one tissue valve. This valvular conduit prosthesis is useful for the reconstruction of the pulmonary artery to correct various types of congenital defects.

Biological valvular prothesis

A method and device for testing artificial or natural venous valves. The device comprises chamber (10) a sample for mounting a test valve (V) on a liquid flow path and a muscle pump component (16) and/or respiratory pump component (50) and/or capacitance reservoir (58) and/or vertical hydrostatic column component (102) fluidly connected to the flow path to mimic the muscle pump, respiratory pump, capacitance and hydrostatic impedance effects on venous circulation in the mammalian body. Included in the invention are methods of testing venous valves by mimicking known hemodynamic flow conditions within a mammalian body.

Method for testing venous valves

A method and device for testing artificial or natural venous valves. The device comprises (a) a fixture for mounting a sample valve on a liquid flow path, (b) a muscle pump component and/or (o) respiratory pump component and/or (d) capacitance reservoir component and/or (e) vertical hydrostatic column component, all of the components being fluidly connected to the flow path to mimic the muscle pump, respiratory pump, capacitance and hydrostatic impedance effects of actual in situ venous circulation in the mammalian body. The invention includes methods of testing venous valves by mimicking known hemodynamic flow conditions within a mammalian body.

Method and device for testing venous valves

A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the treatment of tissue with an effective amount of a surfactant to reduce calcification of the implanted tissue.

Surfactant treatment of implantable biological tissue to inhibit

Calcification resistant bioprosthetic implants are made from tanned biological materials, such as porcine heart valves, bovine pericardium, human dura mater or the like, which has been impregnated with a calcification-mitigating effective amount of a ferric and/or stannic salt. The impregnated biological materials and processes are particularly advantageous for the preparation of bioprosthetic heart valves. These implants have been found to be highly resistant to calcification in vivo.

Calcification mitigation of bioprosthetic implants

Disclosed is a method of interfacing a ligament substitute within a channel of resected bone with a sleeve of soft biological tissue. The sleeve of tissue has overall external dimension sufficient to extend through at least a portion of the resected bone channel and internal dimensions sufficient to receive a ligament substitute therein.

Barrier layer for implantable tendons and ligaments

A process for treating biological tissue prior to implantation to mitigate the calcification of the tissue following implantation comprises incorporating acetylsalicylic acid into the tissue in an amount effective to reduce calcification of the tissue after it is implanted. In accordance with one embodiment, the process involves convalently binding the acetylsalicylic acid to the tissue via a coupling agent.

Calcification mitigation of implantable bioprostheses

Residual aldehyde levels in bioprosthetic tissue are reduced by contacting the tissue with a rinsing solution such that aldehyde which has diffused out of the tissue into the rinsing solution comes into contact with, and reacts with, an amine, thus causing further diffusion of aldehyde out of said tissue. The amine may be dissolved in said rinsing solution or may be immobilized on a solid support to which the rinsing solution is periodically or continuously exposed.

Process for decreasing residual aldehyde levels in implantable

A process for the preparation of implantable biological tissue wherein elastomeric copolymers are incorporated into the tissue in an amount sufficient to increase the durability of the tissue as well as to reduce calcification of the tissue upon implantation. Mitigaton of calcification is retained when the tissue is subjected to flexing, stretching, or similar motion.

Elastomeric polymer incorporation into implantable biological tissue to

A process for selectively incorporating biocompatible polymers in the interstices of implantable biological tissue while leaving the outer surface of the tissue substantially free of bonded polymer. The process involves covalently binding a monomer to the tissue, contacting the tissue with a free-radical initiator, then contacting the tissue with a solution containing a second monomer and a free-radical scavenger, thereby promoting selective polymerization of the second monomer with the portion of covalently-bound first monomer which is located in the interstices of the tissue.

Growing community of inventors

Costa Mesa, CA, United States of America

Aws S Nashef