Massachusetts Institute of Technology

The General Hospital Corporation

Avraham D Schroeder

Daniel Griffith Anderson

Robert Samuel Langer

Christopher G Levins

James E Dahlman

Carlo Giovanni Traverso

Robert S Langer, Jr

Daniel Blankschtein

Carl Magnus Schoellhammer

Robert S Langer

Baris Erinc Polat

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein Rand Rare as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

Conjugated lipomers and uses thereof

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as 'conjugated lipomers' or 'lipomers') containing one or more groups of the formula (iii): wherein Rand Rare as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

The present disclosure provides devices and uses thereof. A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.

Microneedle devices and uses thereof

Growing community of inventors

Newton, MA, United States of America

Avraham D Schroeder